• Publication

    柯宏龍 (Hung-Lung Ke)

    1. Lin, T. C., Chen, G. H., Yeh, C. C., Ke, H. L., Li, W. M., Tsai, Y. C., Wu, S. Y., Huang, C. Y., Chen, C. H., Lin, W. R., Chen, M., Lo, S. H., Pang, S. T., and Lin, P. H. (2024) No difference in oncological outcomes and perioperative complications between patients with ESRD with unilateral and bilateral UTUC receiving radical nephroureterectomy. Sci Rep 14, 17766
    2. Lim, L. M., Lee, Y. C., Lin, T. W., Hong, Z. X., Hsu, W. C., Ke, H. L., Hwang, D. Y., Chung, W. Y., Li, W. M., Lin, H. H., Kuo, H. T., and Huang, A. M. (2024) NTRK3 exhibits a pro-oncogenic function in upper tract urothelial carcinomas. Kaohsiung J Med Sci 40, 445-455
    3. Tu, K. Y., Li, C. C., Li, W. M., Yeh, H. C., Ke, H. L., Wu, W. J., Chien, T. M., Wen, S. C., Wang, Y. C., and Lee, H. Y. (2024) Lipid Profiles Impact on the Oncologic Outcome of Upper Tract Urothelial Carcinoma. World J Oncol 15, 287-297
    4. Huang, T. H., Li, W. M., Ke, H. L., Li, C. C., Wu, W. J., Yeh, H. C., Wang, Y. C., and Lee, H. Y. (2024) The factors impacting on Gleason score upgrading in prostate cancer with initial low Gleason scores. J Formos Med Assoc.
    5. Liang, P. I., Wei, Y. C., Chen, H. D., Ma, Y. C., Ke, H. L.,Chien, C. C., and Chuang, H. W. (2024) TGFB1I1 promotes cell proliferation and migration in urothelial carcinoma. KaohsiungJ Med Sci 40, 269-279
    6. Wang, C.S., Lee, Y.C., Jhan, J.H., Li, W.M., Chang, L.L., Huang, A.M., Lin, H.H., Wu, Y.R., Hsu, W.C.*, and Ke, H.L.*, 2024. MicroRNA-299-3p inhibits cell proliferation, motility, invasion and angiogenesis via VEGFA in upper tract urothelial carcinoma. J Gene Med . 26: e3616.
    7. Li, W.M., Chan, T.C., Wei, Y.C., Li, C.F., Ke, H.L., Wu, W.J., Hsu, C.C., Wang, S.C., Yeh, C.F., 2023. Downregulation of CRTAC1 in Urothelial Carcinoma Promotes Tumor Aggressiveness and Confers Poor Prognosis. Front Biosci (Landmark Ed) 28, 217.
    8. Luo, H.L., Lee, Y.C., Chang,Y.L., Hsu, W.C., Wu, Y.T., Jhan, J.H., Lin, H.H., Wu, Y.R., Ke, H.L.*, and Liu, H.Y.*, 2023. MicroRNA-145-5p suppresses cell proliferation, migration, and invasion in upper tract urothelial carcinoma by targeting 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase. J Cell Biochem . 124, 1324-1345.
    9. Lee, M.R., Li, W.M., Li, C.C., Chou, Y.H., Wu, W.J., Juan,Y.S., Ke, H.L., Wen, S.C., Lee, H.Y., Chien, T.M., 2023. Cumulative sumanalysis of the learning curve of laparoendoscopic single-site robot-assisted radical prostatectomy. Asian J Surg. 46, 3614-3619.
    10. Jhan, J.H., Ke, H.L., Liang, P.I., Hsu, W.C., Lee, Y.C., Lin, H.H., Wu, Y.R., Huang, A.M., Lee, H.Y., Yeh, H.C., Wu, W.J., Li, C.C., Li, W.M., 2023. High MRE11 Expression Level Predicts Poor Survival in Upper Tract Urothelial Carcinomas. Appl Immunohistochem Mol Morphol 31, 94-100.
    11. Wu, K.H., Chang, C.H., Wu, H.C., Huang, S.K., Liu, C.L., Yang, C.K., Li, J.R., Tseng, J.S., Lin, W.R., Yu, C.C., Lo, C.W., Huang, C.Y., Chen, C.H., Tsai, C.Y., Cheng, P.Y., Jiang, Y.H., Lee, Y.K., Chen, Y.T., Yeh, T.C., Lin, J.T., Tsai, Y.C., Hsueh, T.Y., Chiang, B.J., Chiang, Y.D., Lin, W.Y., Jou, Y.C., Pang, S.T., Ke, H.L.*, 2022. Oncologic impact of delay between diagnosis and radical nephroureterectomy. Front Oncol 12, 1025668.
    12. Lim, L.M., Chung, W.Y., Hwang,D.Y., Yu, C.C., Ke, H.L., Liang, P.I., Lin, T.W., Cheng, S.M., Huang, A.M., Kuo, H.T., 2022. Whole-exome sequencing identified mutational profiles of urothelial carcinoma post kidney transplantation. J Transl Med 20, 324.
    13. Yuan, C. H., Hsu, W. C., Huang, A. M., Yuan, B. C., Chen, I. H., Hsu, C. A., Chen, R. F., Chu, Y. M., Lin, H. H., and Ke, H. L*. (2022) MicroRNA-145-5p modulates Kruppel-like factor 5 and inhibits cell proliferation, migration, and invasion in nasopharyngeal carcinoma. BMC Mol Cell Biol 23, 28
    14. Yu, C. C., Chen, C. H., Hong, J. H., Ke, H. L., Li, W. M., Chung, S. D., Wu, W. C., Chen, Y. T., Jiang, Y. H., Lin, Y. H., Lin, W. Y., Wu, C. C., and Tsai, Y. C. (2022) Comparison of oncological outcomes for hand-assisted and pure laparoscopic radical nephroureterectomy: results from the Taiwan Upper Tract Urothelial Cancer Collaboration Group. Surg Endosc 36, 4342-4348
    15. Lo, C. W., Li, W. M., Ke, H. L., Chang, Y. H., Wu, H. C., Chen, I. A., Lin, J. T., Huang, C. Y., Chen, C. H., Tseng, J. S., Lin, W. R., Jiang, Y. H., Lee, Y. K., Tsai, C. Y., Chung, S. D., Hsueh, T. Y., Chiu, A. W., Jou, Y. C., Cheong, I. S., Chen, Y. T., Chen, J. S., Chiang, B. J., Yu, C. C., Lin, W. Y., Wu, C. C., Chen, C. S., Weng, H. Y., and Tsai, Y. C. (2022) Impact of Adjuvant Chemotherapy on Variant Histology of Upper Tract Urothelial Carcinoma: A Propensity Score-Matched Cohort Analysis. Front Oncol 12, 843715
    16. Lin, T. W., Lee, H. Y., Yang, S. F., Li, C. C., Ke, H. L., Li, W. M., Li, C. Y., Tu, H. P., Wu, W. J., and Yeh, H. C. (2022) Perineural Invasion is a Powerful Prognostic Factor for Upper Tract Urothelial Carcinoma Following Radical Nephroureterectomy. Ann Surg Oncol 29, 3306-3317
    17. Lim, L. M., Chung, W. Y., Hwang, D. Y., Yu, C. C., Ke, H. L., Liang, P. I., Lin, T. W., Cheng, S. M., Huang, A. M., and Kuo, H. T. (2022) Whole-exome sequencing identified mutational profiles of urothelial carcinoma post kidney transplantation. J Transl Med 20, 324
    18. Li, W. M., Ke, H. L., Kuo, Y. H., Lai, H. Y., Chan, T. C., Hsing, C. H., Hsieh, K. L., Li, W. S., Chen, T. J., Wei, Y. C., Wu, W. J., Huang, S. K., and Li, C. F. (2022) High MT2A Expression Predicts Worse Prognosis in Patients with Urothelial Carcinoma. Oncology
    19. Lee, M. R., Ke, H. L., Huang, J. C., Huang, S. P., and Geng, J. H. (2022) Obesity-related indices and its association with kidney stone disease: a cross-sectional and longitudinal cohort study. Urolithiasis 50, 55-63
    20. Lee, H. Y., Chang, C. H., Huang, C. P., Yu, C. C., Lo, C. W., Chung, S. D., Wu, W. C., Chen, I. A., Lin, J. T., Jiang, Y. H., Lee, Y. K., Hsueh, T. Y., Chiu, A. W., Chen, Y. T., Lin, C. M., Tsai, Y. C., Chen, W. C., Chiang, B. J., Huang, H. C., Chen, C. H., Huang, C. Y., Wu, C. C., Lin, W. Y., Tseng, J. S., Ke, H. L., and Yeh, H. C. (2022) Is Lymph Node Dissection Necessary During Radical Nephroureterectomy for Clinically Node-Negative Upper Tract Urothelial Carcinoma? A Multi-Institutional Study. Front Oncol 12, 791620
    21. Ke, H. L., Li, C. C., Lee, H. Y., Tu, H. P., Wei, Y. C., Yeh, H. C., Wu, W. J., and Li, W. M. (2022) Prognostic Value of Comorbidity for Patients with Upper Tract Urothelial Carcinoma after Radical Nephroureterectomy. Cancers (Basel) 14
    22. Ke, H. L., Lee, Y. C., Li, W. M., Wang, C. S., Hsu, W. C., Lin, H. H., Lee, Y. A., Jhan, J. H., Li, C. C., Yeh, H. C., Wu, W. J., and Huang, A. M. (2022) High Ubiquitin-Specific Protease 2a Expression Level Predicts Poor Prognosis in Upper Tract Urothelial Carcinoma. Appl Immunohistochem Mol Morphol 30, 304-310
    23. Jhan, J. H., Hsu, W. C., Lee, Y. C., Li, W. M., Huang, A. M., Lin, H. H., Wang, C. S., Wu, Y. R., Li, C. C., Wu, W. J., and Ke, H. L*. (2022) MicroRNA-375-3p Suppresses Upper Tract Urothelial Carcinoma Cell Migration and Invasion via Targeting Derlin-1. Cancers (Basel) 14
    24. Yeh, H. C., Li, C. C., Chien, T. M., Li, C. Y., Cheng, Y. C., Woldu, S. L., Robyak, H., Huang, C. N., Ke, H. L., Li, W. M., Lee, H. Y., Yeh, B. W., Yang, S. F., Tu, H. P., Sagalowsky, A. I., Raman, J. D., Singla, N., Margulis, V., Lotan, Y., Hsieh, J. T., and Wu, W. J. (2021) Interethnic differences in the impact of body mass index on upper tract urothelial carcinoma following radical nephroureterectomy. World J Urol 39, 491-500
    25. Yeh, C. F., Chan, T. C., Ke, H. L., Chen, T. J., Wu, L. C., Lee, H. Y., Wei, Y. C., Wu, W. J., Li, C. F., and Li, W. M. (2021) Prognostic Significance of ROR2 Expression in Patients with Urothelial Carcinoma. Biomedicines 9
    26. Wu, Y. R., Lee, Y. C., Li, W. M., Hsu, W. C., Lin, H. H., Chang, L. L., Huang, A. M., Jhan, J. H., Wu, W. J., Li, C. C., Lee, H. Y., Yeh, H. C., and Ke, H. L*. (2021) High Transaldolase 1 expression predicts poor survival of patients with upper tract urothelial carcinoma. Pathol Int 71, 463-470
    27. Wang, C. S., Guu, S. J., Wang, C. J., Yang, S. F., Ke, H. L., Lee, Y. C., and Jhan, J. H. (2021) A rare noncancerous but life-threatening tumor in urinary bladder. Clin Case Rep 9, 1683-1687
    28. Su, Y. C., Wen, S. C., Li, C. C., Su, H. C., Ke, H. L., Li, W. M., Lee, H. Y., Li, C. Y., Yang, S. F., Tu, H. P., Wu, W. J., and Yeh, H. C. (2021) Low Hemoglobin-to-Red Cell Distribution Width Ratio Is Associated with Disease Progression and Poor Prognosis in Upper Tract Urothelial Carcinoma. Biomedicines 9
    29. Lin, C. H., Wu, W. J., Li, C. C., Ke, H. L., Jhan, J. H., and Wen, S. C. (2021) Comparison of different en bloc holmium laser enucleation of the prostate techniques to reduce the rate of postoperative transient urinary incontinence. J Int Med Res 49, 3000605211037488
    30. Li, C. C., Chien, T. M., Lee, M. R., Lee, H. Y., Ke, H. L., Wen, S. C., Chou, Y. H., and Wu, W. J. (2021) Extraperitoneal Robotic Laparo-Endoscopic Single-Site Plus1-Port Radical Prostatectomy Using the da Vinci Single-Site Platform. J Clin Med 10
    31. Lee, H. Y., Li, C. C., Li, W. M., Hsu, Y. L., Yeh, H. C., Ke, H. L., Yeh, B. W., Huang, C. N., Li, C. F., Kuo, P. L., and Wu, W. J. (2021) Identification of potential genes in upper tract urothelial carcinoma using next-generation sequencing with bioinformatics and in vitro analyses. PeerJ 9, e11343
    32. Lee, H. Y., Chan, E. O., Li, C. C., Leung, D., Li, W. M., Yeh, H. C., Chiu, P. K., Ke, H. L., Yee, C. H., Wong, J. H., Ng, C. F., Teoh, J. Y., and Wu, W. J. (2021) How to manage patients with suspected upper tract urothelial carcinoma in the pandemic of COVID-19? Urol Oncol 39, 733 e711-733 e716
    33. Chien, T. M., Lee, H. Y., Singla, N., Margulis, V., Lotan, Y., Woldu, S. L., Huang, C. N., Li, C. C., Ke, H. L., Li, W. M., Li, C. Y., Huang, A. M., Yang, S. F., Tu, H. P., Wu, W. J., and Yeh, H. C. (2021) Prognostic Factors for Contralateral Recurrence of Upper Tract Urothelial Carcinoma after Nephroureterectomy: A Large Multiregional Study. Cancers (Basel) 13
    34. Chen, T. J., Chan, T. C., Li, W. S., Li, C. F., Ke, H. L., Wei, Y. C., Wu, W. J., and Li, W. M. (2021) Utility of EFEMP1 in the Prediction of Oncologic Outcomes of Urothelial Carcinoma. Genes (Basel) 12
    35. Chang, C. W., Ke, H. L., Lee, J. I., Lee, Y. C., Jhan, J. H., Wang, H. S., Shen, J. T., Tsao, Y. H., Huang, S. P., and Geng, J. H. (2021) Metabolic Syndrome Increases the Risk of Kidney Stone Disease: A Cross-Sectional and Longitudinal Cohort Study. J Pers Med 11
    36. Yu, L. C., Chang, C. H., Huang, C. P., Huang, C. Y., Hong, J. H., Tai, T. Y., Weng, H. Y., Lo, C. W., Tsai, C. Y., Lee, Y. K., Tsai, Y. C., Hsueh, T. Y., Chen, Y. T., Chen, I. H., Chiang, B. J., Tseng, J. S., Wu, C. C., Lin, W. Y., Chien, T. M., Sheu, Z. L., Li, C. C., Ke, H. L., Li, W. M., Lee, H. Y., Wu, W. J., and Yeh, H. C. (2020) Prognostic Significance of Primary Tumor Location in Upper Tract Urothelial Carcinoma Treated with Nephroureterectomy: A Retrospective, Multi-Center Cohort Study in Taiwan. J Clin Med 9
    37. Yeh, H. C., Margulis, V., Singla, N., Hernandez, E., Panwar, V., Woldu, S. L., Karam, J. A., Wood, C. G., Weizer, A. Z., Raman, J. D., Remzi, M., Rioux-Leclercq, N., Haitel, A., Roscigno, M., Bolenz, C., Bensalah, K., Li, C. C., Ke, H. L., Li, W. M., Lee, H. Y., Rapoport, L. M., Lotan, Y., Kapur, P., Shariat, S. F., Hsieh, J. T., and Wu, W. J. (2020) PTRF independently predicts progression and survival in multiracial upper tract urothelial carcinoma following radical nephroureterectomy. Urol Oncol 38, 496-505
    38. Yeh, H. C., Li, C. C., Wen, S. C., Singla, N., Woldu, S. L., Robyak, H., Huang, C. N., Ke, H. L., Li, W. M., Lee, H. Y., Li, C. Y., Yeh, B. W., Yang, S. F., Tu, H. P., Shariat, S. F., Sagalowsky, A. I., Raman, J. D., Lotan, Y., Hsieh, J. T., Margulis, V., and Wu, W. J. (2020) Validation of Hyponatremia as a Prognostic Predictor in Multiregional Upper Tract Urothelial Carcinoma. J Clin Med 9
    39. Wu, Y. H., Jhan, J. H., Ke, H. L., Tseng, S. I., Chang, Y. H., Yeh, H. C., Li, C. C., and Lee, Y. C. (2020) Risk of developing hypertension after hormone therapy for prostate cancer: a nationwide propensity score-matched longitudinal cohort study. Int J Clin Pharm 42, 1433-1439
    40. Li, W. M., Chan, T. C., Huang, S. K., Wu, W. J., Ke, H. L., Liang, P. I., Wei, Y. C., Shiue, Y. L., and Li, C. F. (2020) Prognostic Utility of FBLN2 Expression in Patients With Urothelial Carcinoma. Front Oncol 10, 570340
    41. Li, C. C., Chien, T. M., Huang, S. P., Yeh, H. C., Lee, H. Y., Ke, H. L., Wen, S. C., Chang, W. C., Juan, Y. S., Chou, Y. H., and Wu, W. J. (2020) Single-Site Sutureless Partial Nephrectomy for Small Exophytic Renal Tumors. J Clin Med 9
    42. Hsu, W. C., Li, W. M., Lee, Y. C., Huang, A. M., Chang, L. L., Lin, H. H., Wu, W. J., Li, C. C., Liang, P. I., and Ke, H. L*. (2020) MicroRNA-145 suppresses cell migration and invasion in upper tract urothelial carcinoma by targeting ARF6. FASEB J 34, 5975-5992
    43. Chen, H. W., Tang, J. Y., Chen, Y. C., Wu, W. J., Ke, H. L., and Li, C. C. (2020) Intensity modulation radiation therapy as alternative primary non-surgical treatment of upper tract urothelial carcinoma. Int J Urol 27, 266-268
    44. Lee, H. Y., Chen, Y. J., Li, C. C., Li, W. M., Hsu, Y. L., Yeh, H. C., Ke, H. L., Huang, C. N., Li, C. F., Wu, W. J., and Kuo, P. L. (2019) Deduction of Novel Genes Potentially Involved in Upper Tract Urothelial Carcinoma Using Next-Generation Sequencing and Bioinformatics Approaches. Int J Med Sci 16, 93-105
    45. Lee, H. Y., Chen, Y. J., Chang, W. A., Li, W. M., Ke, H. L., Wu, W. J., and Kuo, P. L. (2019) Effects of Epigallocatechin Gallate (EGCG) on Urinary Bladder Urothelial Carcinoma-Next-Generation Sequencing and Bioinformatics Approaches. Medicina (Kaunas) 55
    46. Jhan, J. H., Lee, Y. C., Li, W. M., Chang, L. L., Hsu, W. C., Lin, H. H., Liang, P. I., Hsu, Y. L., Wu, W. J., Lee, H. Y., Li, C. C., Yeh, H. C., and Ke, H. L*. (2019) The prognostic value of CSN6 expression in upper tract urothelial carcinomas. Kaohsiung J Med Sci 35, 559-565
    47. Huang, Y. T., Li, C. C., Chou, Y. H., Ke, H. L., and Chen, C. Y. (2019) Health-related quality of life of exposed versus non-exposed androgen deprivation therapy patients with prostate cancer: a cross-sectional study. Int J Clin Pharm 41, 993-1003
    48. Hsu, W. C., Lee, Y. C., Liang, P. I., Chang, L. L., Huang, A. M., Lin, H. H., Wu, W. J., Li, C. C., Li, W. M., Jhan, J. H., and Ke, H. L*. (2019) CSF-1 Overexpression Predicts Poor Prognosis in Upper Tract Urothelial Carcinomas. Dis Markers 2019, 2724948
    49. Chen, Y. C., Chen, H. W., Chen, M. T., Huang, C. H., Li, C. C., Juan, Y. S., and Ke, H. L*. (2019) Severe prostate enlargement with severe lower urinary tract symptoms in poorly controlled acromegaly successfully treated with 5alpha-reductase inhibitors: A 15-year longitudinal case report. Low Urin Tract Symptoms 11, O218-O220
    50. Chan, T. C., Li, C. F., Ke, H. L., Wei, Y. C., Shiue, Y. L., Li, C. C., Yeh, H. C., Lee, H. Y., Huang, S. K., Wu, W. J., and Li, W. M. (2019) High TNFAIP6 level is associated with poor prognosis of urothelial carcinomas. Urol Oncol 37, 293 e211-293 e224
    51. Lu, J. H., Liao, W. T., Lee, C. H., Chang, K. L., Ke, H. L., and Yu, H. S. (2018) DeltaNp63 promotes abnormal epidermal proliferation in arsenical skin cancers. Toxicol In Vitro 53, 57-66
    52. Lee, H. Y., Yeh, H. C., Wu, W. J., He, J. S., Huang, C. N., Ke, H. L., Li, W. M., Li, C. F., and Li, C. C. (2018) The diagnostic ureteroscopy before radical nephroureterectomy in upper urinary tract urothelial carcinoma is not associated with higher intravesical recurrence. World J Surg Oncol 16, 135
    53. Lin, S. R., Yeh, H. C., Wang, W. J., Ke, H. L., Lin, H. H., Hsu, W. C., Chao, S. Y., Hour, T. C., Wu, W. J., Pu, Y. S., and Huang, A. M. (2017) MiR-193b Mediates CEBPD-Induced Cisplatin Sensitization Through Targeting ETS1 and Cyclin D1 in Human Urothelial Carcinoma Cells. J Cell Biochem 118, 1563-1573
    54. Liang, P. I., Yeh, B. W., Li, W. M., Chan, T. C., Chang, I. W., Huang, C. N., Li, C. C., Ke, H. L., Yeh, H. C., Wu, W. J., and Li, C. F. (2017) DPP4/CD26 overexpression in urothelial carcinoma confers an independent prognostic impact and correlates with intrinsic biological aggressiveness. Oncotarget 8, 2995-3008
    55. Li, W. M., Huang, C. N., Lee, Y. C., Chen, S. H., Lin, H. H., Wu, W. J., Li, C. C., Yeh, H. C., Chang, L. L., Hsu, W. C., and Ke, H. L*. (2017) Over-expression of Activated Signal Transducer and Activator of Transcription 3 Predicts Poor Prognosis in Upper Tract Urothelial Carcinoma. Int J Med Sci 14, 1360-1367
    56. Lee, Y. C., Wu, W. J., Lin, H. H., Li, W. M., Huang, C. N., Hsu, W. C., Chang, L. L., Li, C. C., Yeh, H. C., Li, C. F., and Ke, H. L*. (2017) Prognostic Value of Leptin Receptor Overexpression in Upper Tract Urothelial Carcinomas in Taiwan. Clin Genitourin Cancer 15, e653-e659
    57. Lee, H. Y., Yeh, B. W., Chan, T. C., Yang, K. F., Li, W. M., Huang, C. N., Ke, H. L., Li, C. C., Yeh, H. C., Liang, P. I., Shiue, Y. L., Wu, W. J., and Li, C. F. (2017) Sulfatase-1 overexpression indicates poor prognosis in urothelial carcinoma of the urinary bladder and upper tract. Oncotarget 8, 47216-47229
    58. Ke, H. L., Li, W. M., Lin, H. H., Hsu, W. C., Hsu, Y. L., Chang, L. L., Huang, C. N., Li, C. C., Chang, H. P., Yeh, H. C., Li, C. F., and Wu, W. J. (2017) Hypoxia-regulated MicroRNA-210 Overexpression is Associated with Tumor Development and Progression in Upper Tract Urothelial Carcinoma. Int J Med Sci 14, 578-584
    59. Yeh, H. C., Huang, C. N., Li, C. C., Chang, L. L., Lin, H. H., Ke, H. L., Huang, A. M., Liang, P. I., Li, C. F., and Wu, W. J. (2016) Overexpression of PTP4A3 is associated with metastasis and unfavorable prognosis in bladder cancer. World J Urol 34, 835-846
    60. Yeh, H. C., Chien, T. M., Wu, W. J., Li, C. C., Li, W. M., Ke, H. L., Chou, Y. H., Wang, C. J., Huang, S. P., Li, C. F., Liang, P. I., and Huang, C. N. (2016) Is preoperative anemia a risk factor for upper tract urothelial carcinoma following radical nephroureterectomy? Urol Oncol 34, 337 e331-339
    61. Tsai, M. C., Li, W. M., Huang, C. N., Ke, H. L., Li, C. C., Yeh, H. C., Chan, T. C., Liang, P. I., Yeh, B. W., Wu, W. J., Lim, S. W., and Li, C. F. (2016) DDR2 overexpression in urothelial carcinoma indicates an unfavorable prognosis: a large cohort study. Oncotarget 7, 78918-78931
    62. Li, W. M., Wei, Y. C., Huang, C. N., Ke, H. L., Li, C. C., Yeh, H. C., Chang, L. L., Huang, C. H., Li, C. F., and Wu, W. J. (2016) Matrix metalloproteinase-11 as a marker of metastasis and predictor of poor survival in urothelial carcinomas. J Surg Oncol 113, 700-707
    63. Li, W. M., Huang, C. N., Ke, H. L., Li, C. C., Wei, Y. C., Yeh, H. C., Chang, L. L., Huang, C. H., Liang, P. I., Yeh, B. W., Chan, T. C., Li, C. F., and Wu, W. J. (2016) MCM10 overexpression implicates adverse prognosis in urothelial carcinoma. Oncotarget 7, 77777-77792
    64. Li, C. C., Yeh, H. C., Lee, H. Y., Li, W. M., Ke, H. L., Hsu, A. H., Lee, M. H., Tsai, C. C., Chueh, K. S., Huang, C. N., Chou, Y. H., Li, C. F., and Wu, W. J. (2016) Laparoscopic partial nephrectomy without intracorporeal suturing. Surg Endosc 30, 1585-1591
    65. Chien, T. M., Lu, Y. M., Geng, J. H., Huang, T. Y., Ke, H. L., Huang, C. N., Li, C. C., Chou, Y. H., Wu, W. J., and Huang, S. P. (2016) Predictors of Positive Bone Metastasis in Newly Diagnosed Prostate Cancer Patients. Asian Pac J Cancer Prev 17, 1187-1191
    66. Cheng, Y. C., Huang, C. N., Wu, W. J., Li, C. C., Ke, H. L., Li, W. M., Tu, H. P., Li, C. F., Chang, L. L., and Yeh, H. C. (2016) The Prognostic Significance of Inflammation-Associated Blood Cell Markers in Patients with Upper Tract Urothelial Carcinoma. Ann Surg Oncol 23, 343-351
    67. Yeh, H. C., Jan, H. C., Wu, W. J., Li, C. C., Li, W. M., Ke, H. L., Huang, S. P., Liu, C. C., Lee, Y. C., Yang, S. F., Liang, P. I., and Huang, C. N. (2015) Concurrent Preoperative Presence of Hydronephrosis and Flank Pain Independently Predicts Worse Outcome of Upper Tract Urothelial Carcinoma. PLoS One 10, e0139624
    68. Liang, P. I., Chen, W. T., Li, C. F., Li, C. C., Li, W. M., Huang, C. N., Yeh, H. C., Ke, H. L., Wu, W. J., and Chai, C. Y. (2015) Subcellular localisation of anillin is associated with different survival outcomes in upper urinary tract urothelial carcinoma. J Clin Pathol 68, 1026-1032
    69. Lee, H. Y., Li, C. C., Huang, C. N., Li, W. M., Yeh, H. C., Ke, H. L., Yang, K. F., Liang, P. I., Li, C. F., and Wu, W. J. (2015) INHBA overexpression indicates poor prognosis in urothelial carcinoma of urinary bladder and upper tract. J Surg Oncol 111, 414-422
    70. Lee, H. Y., Li, C. C., Huang, C. N., Ke, H. L., Li, W. M., Liang, P. I., Yang, S. F., Tu, H. P., Wu, W. J., and Yeh, H. C. (2015) Prognostic significance of lymphovascular invasion in upper urinary tract urothelial carcinoma is influenced by tumor location. Ann Surg Oncol 22, 1392-1400
    71. Ke, H. L., Lin, J., Ye, Y., Wu, W. J., Lin, H. H., Wei, H., Huang, M., Chang, D. W., Dinney, C. P., and Wu, X. (2015) Genetic Variations in Glutathione Pathway Genes Predict Cancer Recurrence in Patients Treated with Transurethral Resection and Bacillus Calmette-Guerin Instillation for Non-muscle Invasive Bladder Cancer. Ann Surg Oncol 22, 4104-4110
    72. Ke, H. L., Lin, H. H., Li, W. M., Li, C. C., Chang, L. L., Lee, Y. C., Huang, C. N., and Wu, W. J. (2015) High visfatin expression predicts poor prognosis of upper tract urothelial carcinoma patients. Am J Cancer Res 5, 2447-2454
    73. Fan, E. W., Li, C. C., Wu, W. J., Huang, C. N., Li, W. M., Ke, H. L., Yeh, H. C., Wu, T. F., Liang, P. I., Ma, L. J., and Li, C. F. (2015) FGF7 Over Expression is an Independent Prognosticator in Patients with Urothelial Carcinoma of the Upper Urinary Tract and Bladder. J Urol 194, 223-229
    74. Wei, H., Ke, H. L., Lin, J., Shete, S., Wood, C. G., and Hildebrandt, M. A. (2014) MicroRNA target site polymorphisms in the VHL-HIF1alpha pathway predict renal cell carcinoma risk. Mol Carcinog 53, 1-7
    75. Li, W. M., Wu, W. J., Li, C. C., Ke, H. L., Wei, Y. C., Yeh, H. C., Chou, Y. H., Huang, C. H., and Huang, C. N. (2013) The effect of tumor location on prognosis in patients with primary ureteral urothelial carcinoma. Urol Oncol 31, 1670-1675
    76. Lee, Y. C., Wu, W. J., Li, W. M., Lin, H. H., Huang, C. N., Chai, C. Y., Chang, L. L., Lin, H. L., and Ke, H. L*. (2013) Prognostic value of p53 protein overexpression in upper tract urothelial carcinomas in Taiwan. Anticancer Res 33, 1091-1098
    77. Ke, H. L., Chen, M., Ye, Y., Hildebrandt, M. A., Wu, W. J., Wei, H., Huang, M., Chang, D. W., Dinney, C. P., and Wu, X. (2013) Genetic variations in micro-RNA biogenesis genes and clinical outcomes in non-muscle-invasive bladder cancer. Carcinogenesis 34, 1006-1011
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    79. Wei, H., Kamat, A., Chen, M., Ke, H. L., Chang, D. W., Yin, J., Grossman, H. B., Dinney, C. P., and Wu, X. (2012) Association of polymorphisms in oxidative stress genes with clinical outcomes for bladder cancer treated with Bacillus Calmette-Guerin. PLoS One 7, e38533
    80. Lin, H. H., Ke, H. L., Wu, W. J., Lee, Y. H., and Chang, L. L. (2012) Hypermethylation of E-cadherin, p16, p14, and RASSF1A genes in pathologically normal urothelium predict bladder recurrence of bladder cancer after transurethral resection. Urol Oncol 30, 177-181
    81. Ke, H. L., Tu, H. P., Lin, H. H., Chai, C. Y., Chang, L. L., Li, W. M., Li, C. C., Lee, Y. C., Yeh, H. C., Wu, W. J., and Bau, D. T. (2012) Cyclooxygenase-2 (COX-2) up-regulation is a prognostic marker for poor clinical outcome of upper tract urothelial cancer. Anticancer Res 32, 4111-4116
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    91. Lin, H. H., Ke, H. L., Huang, S. P., Wu, W. J., Chen, Y. K., and Chang, L. L. (2010) Increase sensitivity in detecting superficial, low grade bladder cancer by combination analysis of hypermethylation of E-cadherin, p16, p14, RASSF1A genes in urine. Urol Oncol 28, 597-602
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    97. Li, C. C., Chang, T. H., Wu, W. J., Ke, H. L., Huang, S. P., Tsai, P. C., Chang, S. J., Shen, J. T., Chou, Y. H., and Huang, C. H. (2008) Significant predictive factors for prognosis of primary upper urinary tract cancer after radical nephroureterectomy in Taiwanese patients. Eur Urol 54, 1127-1134
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    101. Wu, I. C., Wang, S. W., Yang, Y. C., Yu, F. J., Kuo, C. H., Chuang, C. H., Lee, Y. C., Ke, H. L., Kuo, F. C., Chang, L. L., Wang, W. M., Jan, C. M., and Wu, D. C. (2006) Comparison of a new office-based stool immunoassay and (13)C-UBT in the diagnosis of current Helicobacter pylori infection. J Lab Clin Med 147, 145-149
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    詹鎮豪 (Jhen-Hao Jhan)

    1. Wang, C.S., Lee, Y.C., Jhan, J.H., Li, W.M., Chang, L.L., Huang, A.M., Lin, H.H., Wu, Y.R., Hsu, W.C.*, Ke, H.L.*, 2024. MicroRNA-299-3p inhibits cell proliferation, motility, invasion and angiogenesis via VEGFA in upper tract urothelial carcinoma. J Gene Med . 26: e3616.
    2. Chen, Y.H., Geng, J.H., Shen, J.T., Lee, Y.C., Jhan, J.H.*, 2023a. Penile squamous cell carcinoma originating from a silicone granuloma. Urol Case Rep 51, 102595.
    3. Luo, H.L., Lee, Y.C., Chang,Y.L., Hsu, W.C., Wu, Y.T., Jhan, J.H., Lin, H.H., Wu, Y.R., Ke, H.L.*, Liu, H.Y.*, 2023. MicroRNA-145-5p suppresses cell proliferation, migration, and invasion in upper tract urothelial carcinoma by targeting 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase. J Cell Biochem . 124, 1324-1345.
    4. Chen, Y.H., Lee, J.I., Shen, J.T., Wu, Y.H., Tsao, Y.H., Jhan, J.H., Wang, H.S., Lee, Y.C., Huang, S.P., Chen, S.C., Geng, J.H., 2023. The impact of secondhand smoke on the development of kidney stone disease is not inferior to that of smoking: a longitudinal cohort study. BMC Public Health 23, 1189.
    5. Jhan, J.H., Ke, H.L., Liang, P.I., Hsu, W.C., Lee, Y.C., Lin, H.H., Wu, Y.R., Huang, A.M., Lee, H.Y., Yeh, H.C., Wu, W.J., Li, C.C., Li, W.M., 2023. High MRE11 Expression Level Predicts Poor Survival in Upper Tract Urothelial Carcinomas. Appl Immunohistochem Mol Morphol 31, 94-100.
    6. Tang, T.Y., Lee, J.I., Shen, J.T., Lee, Y.C., Wang, H.S., Tsao, Y.H., Wu, Y.H., Huang, S.P., Chen, S.C., Jhan, J.H., Geng, J.H., 2023. The association between menopause, postmenopausal hormone therapy, and kidney stone disease in Taiwanese women. Ann Epidemiol 78, 13-18.
    7. Liu, C. C., Wu, C. F., Lee, Y. C., Huang, T. Y., Huang, S. T., Wang, H. S., Jhan, J. H., Huang, S. P., Li, C. C., Juan, Y. S., Hsieh, T. J., Tsai, Y. C., Chen, C. C., and Wu, M. T. (2022) Genetic Polymorphisms of MnSOD Modify the Impacts of Environmental Melamine on Oxidative Stress and Early Kidney Injury in Calcium Urolithiasis Patients. Antioxidants (Basel) 11
    8. Li, C. C., Lin, B. S., Wen, S. C., Liang, Y. T., Sung, H. Y., Jhan, J. H., and Lin, B. S. (2022) Smart Blood Vessel Detection System for Laparoscopic Surgery. IEEE J Transl Eng Health Med 10, 2500207
    9. Ke, H. L., Lee, Y. C., Li, W. M., Wang, C. S., Hsu, W. C., Lin, H. H., Lee, Y. A., Jhan, J. H., Li, C. C., Yeh, H. C., Wu, W. J., and Huang, A. M. (2022) High Ubiquitin-Specific Protease 2a Expression Level Predicts Poor Prognosis in Upper Tract Urothelial Carcinoma. Appl Immunohistochem Mol Morphol 30, 304-310
    10. Jhan, J. H., Hsu, W. C., Lee, Y. C., Li, W. M., Huang, A. M., Lin, H. H., Wang, C. S., Wu, Y. R., Li, C. C., Wu, W. J., and Ke, H. L. (2022) MicroRNA-375-3p Suppresses Upper Tract Urothelial Carcinoma Cell Migration and Invasion via Targeting Derlin-1. Cancers (Basel) 14
    11. Chang, C. K., Lee, J. I., Chang, C. F., Lee, Y. C., Jhan, J. H., Wang, H. S., Shen, J. T., Tsao, Y. H., Huang, S. P., and Geng, J. H. (2022) Betel Nut Chewing Is Associated with the Risk of Kidney Stone Disease. J Pers Med 12
    12. Wu, Y. R., Lee, Y. C., Li, W. M., Hsu, W. C., Lin, H. H., Chang, L. L., Huang, A. M., Jhan, J. H., Wu, W. J., Li, C. C., Lee, H. Y., Yeh, H. C., and Ke, H. L. (2021) High Transaldolase 1 expression predicts poor survival of patients with upper tract urothelial carcinoma. Pathol Int 71, 463-470
    13. Wang, C. S., Guu, S. J., Wang, C. J., Yang, S. F., Ke, H. L., Lee, Y. C., and Jhan, J. H*. (2021) A rare noncancerous but life-threatening tumor in urinary bladder. Clin Case Rep 9, 1683-1687
    14. Lin, C. H., Wu, W. J., Li, C. C., Ke, H. L., Jhan, J. H., and Wen, S. C. (2021) Comparison of different en bloc holmium laser enucleation of the prostate techniques to reduce the rate of postoperative transient urinary incontinence. J Int Med Res 49, 3000605211037488
    15. Lee, Y. C., Hsieh, T. J., Tang, F. H., Jhan, J. H., Lin, K. L., Juan, Y. S., Wang, H. S., and Long, C. Y. (2021) Therapeutic effect of Low intensity Extracorporeal Shock Wave Therapy (Li-ESWT) on diabetic bladder dysfunction in a rat model. Int J Med Sci 18, 1423-1431
    16. Chen, C. H., Lee, J. I., Jhan, J. H., Lee, Y. C., Geng, J. H., Chen, S. C., Hung, C. H., and Kuo, C. H. (2021) Secondhand smoke increases the risk of developing kidney stone disease. Sci Rep 11, 17694
    17. Chang, C. W., Ke, H. L., Lee, J. I., Lee, Y. C., Jhan, J. H., Wang, H. S., Shen, J. T., Tsao, Y. H., Huang, S. P., and Geng, J. H. (2021) Metabolic Syndrome Increases the Risk of Kidney Stone Disease: A Cross-Sectional and Longitudinal Cohort Study. J Pers Med 11
    18. Wu, Y. H., Juan, Y. S., Shen, J. T., Wang, H. S., Jhan, J. H., Lee, Y. C., and Geng, J. H. (2020) Lower urinary tract symptoms-Benign prostatic hyperplasia may increase the risk of subsequent inguinal hernia in a Taiwanese population: A nationwide population-Based cohort study. PLoS One 15, e0234329
    19. Wu, Y. H., Jhan, J. H., Ke, H. L., Tseng, S. I., Chang, Y. H., Yeh, H. C., Li, C. C., and Lee, Y. C. (2020) Risk of developing hypertension after hormone therapy for prostate cancer: a nationwide propensity score-matched longitudinal cohort study. Int J Clin Pharm 42, 1433-1439
    20. Tsao, Y. H., Hsieh, C. J., Juan, Y. S., Lee, Y. C., Shen, J. T., Wang, H. S., Jhan, J. H., and Geng, J. H. (2020) Herpes zoster and the subsequent risk of prostate cancer in an Asian population: A nationwide population-based cohort study. Medicine (Baltimore) 99, e22441
    21. Chang, H. H., Jhan, J. H., and Huang, T. Y. (2020) Distal ureteral stone in an ileal conduit: A case treated by antegrade flexible ureteroscopic lithotripsy. Clin Case Rep 8, 2809-2812
    22. Chang, C. W., Tang, S. H., Su, C. H., Tsai, K. B., Lee, Y. C., and Jhan, J. H*. (2020) IgG4-related disease mimicking renal pelvis tumor with peritoneal carcinomatosis. Clin Case Rep 8, 2040-2045
    23. Wang, C. S., Jhan, J. H., and Li, C. C. (2019) Re: Prostate Specific Antigen Density as a Predictor of Clinically Significant Prostate Cancer when the Prostate Specific Antigen is in the Diagnostic Gray Zone: .: A. Aminsharifi, L. Howard, Y. Wu, A. De Hoedt, C. Bailey, S. J. Freedland and T. J. Polascik J Urol 2018; 200: 758-766. J Urol 201, 627-628
    24. Jhan, J. H., Lee, Y. C., Li, W. M., Chang, L. L., Hsu, W. C., Lin, H. H., Liang, P. I., Hsu, Y. L., Wu, W. J., Lee, H. Y., Li, C. C., Yeh, H. C., and Ke, H. L. (2019) The prognostic value of CSN6 expression in upper tract urothelial carcinomas. Kaohsiung J Med Sci 35, 559-565
    25. Hsu, W. C., Lee, Y. C., Liang, P. I., Chang, L. L., Huang, A. M., Lin, H. H., Wu, W. J., Li, C. C., Li, W. M., Jhan, J. H., and Ke, H. L. (2019) CSF-1 Overexpression Predicts Poor Prognosis in Upper Tract Urothelial Carcinomas. Dis Markers 2019, 2724948
    26. Chen, Y. C., Chen, H. W., Juan, Y. S., Lo, I. S., Shih, M. P., Wu, W. J., Jhan, J. H., and Huang, T. Y. (2019) Management of Large Proximal Ureteral Calculi: A Three-year Multicenter Experience of Simultaneous Supine Percutaneous Nephrolithotomy and Retrograde Ureterolithotripsy. Urol J 16, 433-438
    27. Jhan, J. H., Yeh, H. C., Chang, Y. H., Guu, S. J., Wu, W. J., Chou, Y. H., and Li, C. C. (2018) New-onset diabetes after androgen-deprivation therapy for prostate cancer: A nationwide propensity score-matched four-year longitudinal cohort study. J Diabetes Complications 32, 688-692
    28. Jhan, J. H., Li, C. C., Wu, W. J., and Lee, H. Y. (2018) Isolated retroperitoneal Castleman's disease: A case report and literature review. Clin Case Rep 6, 1543-1548
    29. Jhan, J. H., Yang, Y. H., Chang, Y. H., Guu, S. J., and Tsai, C. C. (2017) Hormone therapy for prostate cancer increases the risk of Alzheimer's disease: a nationwide 4-year longitudinal cohort study. Aging Male 20, 33-38

     

    林慧惠 (Hui-Hui Lin)

    1. Wang, C.S., Lee, Y.C., Jhan, J.H., Li, W.M., Chang, L.L., Huang, A.M., Lin, H.H., Wu, Y.R., Hsu, W.C.*, Ke, H.L.*, 2024. MicroRNA-299-3p inhibits cell proliferation, motility, invasion and angiogenesis via VEGFA in upper tract urothelial carcinoma. J Gene Med . 26: e3616.
    2. Luo, H.L., Lee, Y.C., Chang,Y.L., Hsu, W.C., Wu, Y.T., Jhan, J.H., Lin, H.H., Wu, Y.R., Ke, H.L.*, Liu, H.Y.*, 2023. MicroRNA-145-5p suppresses cell proliferation, migration, and invasion in upper tract urothelial carcinoma by targeting 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase. J Cell Biochem . 124, 1324-1345.
    3. Jhan, J.H., Ke, H.L., Liang, P.I., Hsu, W.C., Lee, Y.C., Lin, H.H., Wu, Y.R., Huang, A.M., Lee, H.Y., Yeh, H.C., Wu, W.J., Li, C.C., Li, W.M., 2023. High MRE11 Expression Level Predicts Poor Survival in Upper Tract Urothelial Carcinomas. Appl Immunohistochem Mol Morphol 31, 94-100.
    4. Yuan, C. H., Hsu, W. C., Huang, A. M., Yuan, B. C., Chen, I. H., Hsu, C. A., Chen, R. F., Chu, Y. M., Lin, H. H., and Ke, H. L. (2022) MicroRNA-145-5p modulates Kruppel-like factor 5 and inhibits cell proliferation, migration, and invasion in nasopharyngeal carcinoma. BMC Mol Cell Biol 23, 28
    5. Ke, H. L., Lee, Y. C., Li, W. M., Wang, C. S., Hsu, W. C., Lin, H. H., Lee, Y. A., Jhan, J. H., Li, C. C., Yeh, H. C., Wu, W. J., and Huang, A. M. (2022) High Ubiquitin-Specific Protease 2a Expression Level Predicts Poor Prognosis in Upper Tract Urothelial Carcinoma. Appl Immunohistochem Mol Morphol 30, 304-310
    6. Jhan, J. H., Hsu, W. C., Lee, Y. C., Li, W. M., Huang, A. M., Lin, H. H., Wang, C. S., Wu, Y. R., Li, C. C., Wu, W. J., and Ke, H. L. (2022) MicroRNA-375-3p Suppresses Upper Tract Urothelial Carcinoma Cell Migration and Invasion via Targeting Derlin-1. Cancers (Basel) 14
    7. Wu, Y. R., Lee, Y. C., Li, W. M., Hsu, W. C., Lin, H. H., Chang, L. L., Huang, A. M., Jhan, J. H., Wu, W. J., Li, C. C., Lee, H. Y., Yeh, H. C., and Ke, H. L. (2021) High Transaldolase 1 expression predicts poor survival of patients with upper tract urothelial carcinoma. Pathol Int 71, 463-470
    8. Hsu, W. C., Li, W. M., Lee, Y. C., Huang, A. M., Chang, L. L., Lin, H. H., Wu, W. J., Li, C. C., Liang, P. I., and Ke, H. L. (2020) MicroRNA-145 suppresses cell migration and invasion in upper tract urothelial carcinoma by targeting ARF6. FASEB J 34, 5975-5992
    9. Jhan, J. H., Lee, Y. C., Li, W. M., Chang, L. L., Hsu, W. C., Lin, H. H., Liang, P. I., Hsu, Y. L., Wu, W. J., Lee, H. Y., Li, C. C., Yeh, H. C., and Ke, H. L. (2019) The prognostic value of CSN6 expression in upper tract urothelial carcinomas. Kaohsiung J Med Sci 35, 559-565
    10. Hsu, W. C., Lee, Y. C., Liang, P. I., Chang, L. L., Huang, A. M., Lin, H. H., Wu, W. J., Li, C. C., Li, W. M., Jhan, J. H., and Ke, H. L. (2019) CSF-1 Overexpression Predicts Poor Prognosis in Upper Tract Urothelial Carcinomas. Dis Markers 2019, 2724948
    11. Lin, S. R., Yeh, H. C., Wang, W. J., Ke, H. L., Lin, H. H., Hsu, W. C., Chao, S. Y., Hour, T. C., Wu, W. J., Pu, Y. S., and Huang, A. M. (2017) MiR-193b Mediates CEBPD-Induced Cisplatin Sensitization Through Targeting ETS1 and Cyclin D1 in Human Urothelial Carcinoma Cells. J Cell Biochem 118, 1563-1573
    12. Li, W. M., Huang, C. N., Lee, Y. C., Chen, S. H., Lin, H. H., Wu, W. J., Li, C. C., Yeh, H. C., Chang, L. L., Hsu, W. C., and Ke, H. L. (2017) Over-expression of Activated Signal Transducer and Activator of Transcription 3 Predicts Poor Prognosis in Upper Tract Urothelial Carcinoma. Int J Med Sci 14, 1360-1367
    13. Lee, Y. C., Wu, W. J., Lin, H. H., Li, W. M., Huang, C. N., Hsu, W. C., Chang, L. L., Li, C. C., Yeh, H. C., Li, C. F., and Ke, H. L. (2017) Prognostic Value of Leptin Receptor Overexpression in Upper Tract Urothelial Carcinomas in Taiwan. Clin Genitourin Cancer 15, e653-e659
    14. Ke, H. L., Li, W. M., Lin, H. H., Hsu, W. C., Hsu, Y. L., Chang, L. L., Huang, C. N., Li, C. C., Chang, H. P., Yeh, H. C., Li, C. F., and Wu, W. J. (2017) Hypoxia-regulated MicroRNA-210 Overexpression is Associated with Tumor Development and Progression in Upper Tract Urothelial Carcinoma. Int J Med Sci 14, 578-584
    15. Yeh, H. C., Huang, C. N., Li, C. C., Chang, L. L., Lin, H. H., Ke, H. L., Huang, A. M., Liang, P. I., Li, C. F., and Wu, W. J. (2016) Overexpression of PTP4A3 is associated with metastasis and unfavorable prognosis in bladder cancer. World J Urol 34, 835-846
    16. Ke, H. L., Lin, J., Ye, Y., Wu, W. J., Lin, H. H., Wei, H., Huang, M., Chang, D. W., Dinney, C. P., and Wu, X. (2015) Genetic Variations in Glutathione Pathway Genes Predict Cancer Recurrence in Patients Treated with Transurethral Resection and Bacillus Calmette-Guerin Instillation for Non-muscle Invasive Bladder Cancer. Ann Surg Oncol 22, 4104-4110
    17. Ke, H. L., Lin, H. H., Li, W. M., Li, C. C., Chang, L. L., Lee, Y. C., Huang, C. N., and Wu, W. J. (2015) High visfatin expression predicts poor prognosis of upper tract urothelial carcinoma patients. Am J Cancer Res 5, 2447-2454
    18. Lee, Y. C., Wu, W. J., Li, W. M., Lin, H. H., Huang, C. N., Chai, C. Y., Chang, L. L., Lin, H. L., and Ke, H. L. (2013) Prognostic value of p53 protein overexpression in upper tract urothelial carcinomas in Taiwan. Anticancer Res 33, 1091-1098
    19. Chen, S. H., Wu, W. J., Tu, H. P., Li, W. M., Huang, C. N., Li, C. C., Lin, H. H., and Ke, H. L. (2013) Glutathione S-transferase expression in upper urinary tract urothelial carcinomas: a Taiwan study. Asian Pac J Cancer Prev 14, 6475-6479
    20. Ke, H. L., Tu, H. P., Lin, H. H., Chai, C. Y., Chang, L. L., Li, W. M., Li, C. C., Lee, Y. C., Yeh, H. C., Wu, W. J., and Bau, D. T. (2012) Cyclooxygenase-2 (COX-2) up-regulation is a prognostic marker for poor clinical outcome of upper tract urothelial cancer. Anticancer Res 32, 4111-4116
    21. Chang, W. S., Ke, H. L., Tsai, C. W., Lien, C. S., Liao, W. L., Lin, H. H., Lee, M. H., Wu, H. C., Chang, C. H., Chen, C. C., Lee, H. Z., and Bau, D. T. (2012) The role of XRCC6 T-991C functional polymorphism in renal cell carcinoma. Anticancer Res 32, 3855-3860
    22. Lin, H. H., Ke, H. L., Wu, W. J., Lee, Y. H., and Chang, L. L. (2012) Hypermethylation of E-cadherin, p16, p14, and RASSF1A genes in pathologically normal urothelium predict bladder recurrence of bladder cancer after transurethral resection. Urol Oncol 30, 177-181
    23. Ke, H. L., Chang, L. L., Yang, S. F., Lin, H. H., Li, C. C., Wu, D. C., and Wu, W. J. (2011) Osteopontin overexpression predicts poor prognosis of upper urinary tract urothelial carcinoma. Urol Oncol 29, 703-709
    24. Lin, H. H., Ke, H. L., Hsiao, K. H., Tsai, C. W., Wu, W. J., Bau, D. T., and Chang, L. L. (2011) Potential role of CCND1 G870A genotype as a predictor for urothelial carcinoma susceptibility and muscle-invasiveness in Taiwan. Chin J Physiol 54, 196-202
    25. Lin, H. H., Ke, H. L., Hsiao, K. H., Tsai, C. W., Wu, W. J., Bau, D. T., and Chang, L. L. (2011) CCND1 1722 polymorphism and potential relevance to upper tract urothelial cancer. Anticancer Res 31, 1043-1047
    26. Wu, H. C., Chang, C. H., Ke, H. L., Chang, W. S., Cheng, H. N., Lin, H. H., Wu, C. Y., Tsai, C. W., Tsai, R. Y., Lo, W. C., and Bau, D. T. (2011) Association of cyclooxygenase 2 polymorphic genotypes with prostate cancer in taiwan. Anticancer Res 31, 221-225
    27. Lin, H. H., Ke, H. L., Huang, S. P., Wu, W. J., Chen, Y. K., and Chang, L. L. (2010) Increase sensitivity in detecting superficial, low grade bladder cancer by combination analysis of hypermethylation of E-cadherin, p16, p14, RASSF1A genes in urine. Urol Oncol 28, 597-602
    28. Yeh, H. C., Huang, C. H., Yang, S. F., Li, C. C., Chang, L. L., Lin, H. H., Ke, H. L., Wei, Y. C., and Wu, W. J. (2010) Nuclear factor-kappaB activation predicts an unfavourable outcome in human upper urinary tract urothelial carcinoma. BJU Int 106, 1223-1229
    29. Lee, Y. C., Lin, H. H., Wang, C. J., Liu, C. C., Wu, W. J., Huang, C. H., and Chang, L. L. (2008) The associations among GNB3 C825T polymorphism, erectile dysfunction, and related risk factors. J Sex Med 5, 2061-2068
    30. Lee, Y. C., Huang, C. H., Wang, C. J., Liu, C. C., Wu, W. J., Chang, L. L., and Lin, H. H*. (2007) The associations among eNOS G894T gene polymorphism, erectile dysfunction and related risk factors. BJU Int 100, 1116-1120
    31. Chang, L. L., Lin, H. H., Chang, C. Y., and Lu, P. L. (2007) Increased incidence of class 1 integrons in trimethoprim/sulfamethoxazole-resistant clinical isolates of Stenotrophomonas maltophilia. J Antimicrob Chemother 59, 1038-1039

    徐偉齊 (Wei-Chi Hsu)

    1. Lim, L. M., Lee, Y. C., Lin, T. W., Hong, Z. X., Hsu, W. C., Ke, H. L., Hwang, D. Y., Chung, W. Y., Li, W. M., Lin, H. H., Kuo, H. T., and Huang, A. M. (2024) NTRK3 exhibits a pro-oncogenic function in upper tract urothelial carcinomas. Kaohsiung J Med Sci 40, 445-455
    2. Wang, C.S., Lee, Y.C., Jhan, J.H., Li, W.M., Chang, L.L., Huang, A.M., Lin, H.H., Wu, Y.R., Hsu, W.C.*, and Ke, H.L.*, 2024. MicroRNA-299-3p inhibits cell proliferation, motility, invasion and angiogenesis via VEGFA in upper tract urothelial carcinoma. J Gene Med . 26: e3616.
    3. Luo, H.L., Lee, Y.C., Chang,Y.L., Hsu, W.C., Wu, Y.T., Jhan, J.H., Lin, H.H., Wu, Y.R., Ke, H.L.*, Liu, H.Y.*, 2023. MicroRNA-145-5p suppresses cell proliferation, migration, and invasion in upper tract urothelial carcinoma by targeting 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase. J Cell Biochem.
    4. Jhan, J.H., Ke, H.L., Liang, P.I., Hsu, W.C., Lee, Y.C., Lin, H.H., Wu, Y.R., Huang, A.M., Lee, H.Y., Yeh, H.C., Wu, W.J., Li, C.C., Li, W.M., 2023. High MRE11 Expression Level Predicts Poor Survival in Upper Tract Urothelial Carcinomas. Appl Immunohistochem Mol Morphol 31, 94-100.
    5. Yuan, C. H., Hsu, W. C., Huang, A. M., Yuan, B. C., Chen, I. H., Hsu, C. A., Chen, R. F., Chu, Y. M., Lin, H. H., and Ke, H. L. (2022) MicroRNA-145-5p modulates Kruppel-like factor 5 and inhibits cell proliferation, migration, and invasion in nasopharyngeal carcinoma. BMC Mol Cell Biol 23, 28
    6. Ke, H. L., Lee, Y. C., Li, W. M., Wang, C. S., Hsu, W. C., Lin, H. H., Lee, Y. A., Jhan, J. H., Li, C. C., Yeh, H. C., Wu, W. J., and Huang, A. M. (2022) High Ubiquitin-Specific Protease 2a Expression Level Predicts Poor Prognosis in Upper Tract Urothelial Carcinoma. Appl Immunohistochem Mol Morphol 30, 304-310
    7. Jhan, J. H., Hsu, W. C., Lee, Y. C., Li, W. M., Huang, A. M., Lin, H. H., Wang, C. S., Wu, Y. R., Li, C. C., Wu, W. J., and Ke, H. L. (2022) MicroRNA-375-3p Suppresses Upper Tract Urothelial Carcinoma Cell Migration and Invasion via Targeting Derlin-1. Cancers (Basel) 14
    8. Wu, Y. R., Lee, Y. C., Li, W. M., Hsu, W. C., Lin, H. H., Chang, L. L., Huang, A. M., Jhan, J. H., Wu, W. J., Li, C. C., Lee, H. Y., Yeh, H. C., and Ke, H. L. (2021) High Transaldolase 1 expression predicts poor survival of patients with upper tract urothelial carcinoma. Pathol Int 71, 463-470
    9. Hsu, W. C., Li, W. M., Lee, Y. C., Huang, A. M., Chang, L. L., Lin, H. H., Wu, W. J., Li, C. C., Liang, P. I., and Ke, H. L. (2020) MicroRNA-145 suppresses cell migration and invasion in upper tract urothelial carcinoma by targeting ARF6. FASEB J 34, 5975-5992
    10. Jhan, J. H., Lee, Y. C., Li, W. M., Chang, L. L., Hsu, W. C., Lin, H. H., Liang, P. I., Hsu, Y. L., Wu, W. J., Lee, H. Y., Li, C. C., Yeh, H. C., and Ke, H. L. (2019) The prognostic value of CSN6 expression in upper tract urothelial carcinomas. Kaohsiung J Med Sci 35, 559-565
    11. Hsu, W. C., Lee, Y. C., Liang, P. I., Chang, L. L., Huang, A. M., Lin, H. H., Wu, W. J., Li, C. C., Li, W. M., Jhan, J. H., and Ke, H. L. (2019) CSF-1 Overexpression Predicts Poor Prognosis in Upper Tract Urothelial Carcinomas. Dis Markers 2019, 2724948
    12. Lin, S. R., Yeh, H. C., Wang, W. J., Ke, H. L., Lin, H. H., Hsu, W. C., Chao, S. Y., Hour, T. C., Wu, W. J., Pu, Y. S., and Huang, A. M. (2017) MiR-193b Mediates CEBPD-Induced Cisplatin Sensitization Through Targeting ETS1 and Cyclin D1 in Human Urothelial Carcinoma Cells. J Cell Biochem 118, 1563-1573
    13. Li, W. M., Huang, C. N., Lee, Y. C., Chen, S. H., Lin, H. H., Wu, W. J., Li, C. C., Yeh, H. C., Chang, L. L., Hsu, W. C., and Ke, H. L. (2017) Over-expression of Activated Signal Transducer and Activator of Transcription 3 Predicts Poor Prognosis in Upper Tract Urothelial Carcinoma. Int J Med Sci 14, 1360-1367
    14. Lee, Y. C., Wu, W. J., Lin, H. H., Li, W. M., Huang, C. N., Hsu, W. C., Chang, L. L., Li, C. C., Yeh, H. C., Li, C. F., and Ke, H. L. (2017) Prognostic Value of Leptin Receptor Overexpression in Upper Tract Urothelial Carcinomas in Taiwan. Clin Genitourin Cancer 15, e653-e659
    15. Ke, H. L., Li, W. M., Lin, H. H., Hsu, W. C., Hsu, Y. L., Chang, L. L., Huang, C. N., Li, C. C., Chang, H. P., Yeh, H. C., Li, C. F., and Wu, W. J. (2017) Hypoxia-regulated MicroRNA-210 Overexpression is Associated with Tumor Development and Progression in Upper Tract Urothelial Carcinoma. Int J Med Sci 14, 578-584
    16. Lin, K. W., Huang, A. M., Lin, C. C., Chang, C. C., Hsu, W. C., Hour, T. C., Pu, Y. S., and Lin, C. N. (2014) Anti-cancer effects of ursane triterpenoid as a single agent and in combination with cisplatin in bladder cancer. Eur J Pharmacol 740, 742-751
    17. Kao, Y. T., Hsu, W. C., Hu, H. T., Hsu, S. H., Lin, C. S., Chiu, C. C., Lu, C. Y., Hour, T. C., Pu, Y. S., and Huang, A. M. (2014) Involvement of p38 mitogen-activated protein kinase in acquired gemcitabine-resistant human urothelial carcinoma sublines. Kaohsiung J Med Sci 30, 323-330

    王建勝 (Chien-Sheng Wang)

    1. Wang, C.S., Lee, Y.C., Jhan, J.H., Li, W.M., Chang, L.L., Huang, A.M., Lin, H.H., Wu, Y.R., Hsu, W.C.*, and Ke, H.L.*, 2024. MicroRNA-299-3p inhibits cell proliferation, motility, invasion and angiogenesis via VEGFA in upper tract urothelial carcinoma. J Gene Med . 26: e3616.
    2. Lee, H.Y., Wang, C.S., Juan,Y.S., 2022. Detrusor Underactivity in Men with Bladder Outlet Obstruction. Biomedicines 10.
    3. Ke, H. L., Lee, Y. C., Li, W. M., Wang, C. S., Hsu, W. C., Lin, H. H., Lee, Y. A., Jhan, J. H., Li, C. C., Yeh, H. C., Wu, W. J., and Huang, A. M. (2022) High Ubiquitin-Specific Protease 2a Expression Level Predicts Poor Prognosis in Upper Tract Urothelial Carcinoma. Appl Immunohistochem Mol Morphol 30, 304-310
    4. Jhan, J. H., Hsu, W. C., Lee, Y. C., Li, W. M., Huang, A. M., Lin, H. H., Wang, C. S., Wu, Y. R., Li, C. C., Wu, W. J., and Ke, H. L. (2022) MicroRNA-375-3p Suppresses Upper Tract Urothelial Carcinoma Cell Migration and Invasion via Targeting Derlin-1. Cancers (Basel) 14
    5. Wang, C. S., Li, C. C., Wu, W. J., Liou, W. C., Lin, Y. E., and Chen, W. C. (2021) Newly designed solid coupling medium for reducing trapped air pockets during extracorporeal shock wave lithotripsy_ a phantom study. BMC Urol 21, 79
    6. Wang, C. S., Guu, S. J., Wang, C. J., Yang, S. F., Ke, H. L., Lee, Y. C., and Jhan, J. H. (2021) A rare noncancerous but life-threatening tumor in urinary bladder. Clin Case Rep 9, 1683-1687
    7. Wang, C. S., Li, C. C., Juan, Y. S., Wu, W. J., and Lee, H. Y. (2020) 5alpha-reductase inhibitors impact prognosis of urothelial carcinoma. BMC Cancer 20, 872

     

    張哲維 (Che-Wei Chang)

    1. Liu, C.C., Huang, S.P., Lee, Y.C., Lee, C.H., Huang, T.Y., Geng, J.H., Chang, C.W., Lin, C.Y., Juan, Y.S., Wu, W.J., Hsieh, T.J., 2023. Metabolic dysfunction-associated fatty liver disease is an early predictor for testosterone deficiency in aging men without metabolic syndrome. Front Endocrinol (Lausanne) 14, 1252774.
    2. Chang, C.W., Tang, T.Y., Geng, J.H., Jhan, J.H., Wang, H.S., Shen, J.T., Lee, Y.C., 2022. The Safety and Efficacy of Vela Laser En-Bloc Endoscopic Resection versus Conventional Transurethral Resection of Bladder Tumor-A Single Center Experience. J Clin Med 11.
    3. Chang, C. W., Ke, H. L., Lee, J. I., Lee, Y. C., Jhan, J. H., Wang, H. S., Shen, J. T., Tsao, Y. H., Huang, S. P., and Geng, J. H. (2021) Metabolic Syndrome Increases the Risk of Kidney Stone Disease: A Cross-Sectional and Longitudinal Cohort Study. J Pers Med 11
    4. Chang, C. W., Yin, H. L., and Li, C. C. (2021) Primary clear cell adenocarcinoma of prostate: A diagnostic challenge. Urol Ann 13, 434-437
    5. Chang, C. W., Ou, C. H., Yu, C. C., Lo, C. W., Tsai, C. Y., Cheng, P. Y., Chen, Y. T., Huang, H. C., Wu, C. C., Li, C. C., and Lee, H. Y. (2021) Comparative analysis of patients with upper urinary tract urothelial carcinoma in black-foot disease endemic and non-endemic area. BMC Cancer 21, 80
    6. Chang, C. W., Juan, Y. S., Yang, Y. H., and Lee, H. Y. (2021) The Relationship Between Lower Urinary Tract Symptoms and Severity of Alzheimer's Disease. Am J Alzheimers Dis Other Demen 36, 1533317521992657
    7. Chang, C. W., Chien, C. C., Juan, Y. S., and Chueh, K. S. (2021) Primary renal angiosarcoma mimicking urothelial carcinoma - A case report and literature reviews. Urol Case Rep 34, 101407
    8. Chang, C. W., and Huang, C. N. (2020) Pyonephrosis drained by double-J catheter. Clin Case Rep 8, 3586-3587
    9. Chang, C. W., Tang, S. H., Su, C. H., Tsai, K. B., Lee, Y. C., and Jhan, J. H. (2020) IgG4-related disease mimicking renal pelvis tumor with peritoneal carcinomatosis. Clin Case Rep 8, 2040-2045

    吳奕儒 (Yi-Ru Wu)

    1. Wang, C.S., Lee, Y.C., Jhan, J.H., Li, W.M., Chang, L.L., Huang, A.M., Lin, H.H., Wu, Y.R., Hsu, W.C.*, Ke, H.L.*, 2024. MicroRNA-299-3p inhibits cell proliferation, motility, invasion and angiogenesis via VEGFA in upper tract urothelial carcinoma. J Gene Med . 26: e3616.
    2. Luo, H.L., Lee, Y.C., Chang,Y.L., Hsu, W.C., Wu, Y.T., Jhan, J.H., Lin, H.H., Wu, Y.R., Ke, H.L.*, Liu, H.Y.*, 2023. MicroRNA-145-5p suppresses cell proliferation, migration, and invasion in upper tract urothelial carcinoma by targeting 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase. J Cell Biochem.
    3. Jhan, J.H., Ke, H.L., Liang, P.I., Hsu, W.C., Lee, Y.C., Lin, H.H., Wu, Y.R., Huang, A.M., Lee, H.Y., Yeh, H.C., Wu, W.J., Li, C.C., Li, W.M., 2023. High MRE11 Expression Level Predicts Poor Survival in Upper Tract Urothelial Carcinomas. Appl Immunohistochem Mol Morphol 31, 94-100.
    4. Jhan, J. H., Hsu, W. C., Lee, Y. C., Li, W. M., Huang, A. M., Lin, H. H., Wang, C. S., Wu, Y. R., Li, C. C., Wu, W. J., and Ke, H. L. (2022) MicroRNA-375-3p Suppresses Upper Tract Urothelial Carcinoma Cell Migration and Invasion via Targeting Derlin-1. Cancers (Basel) 14
    5. Wu, Y. R., Lee, Y. C., Li, W. M., Hsu, W. C., Lin, H. H., Chang, L. L., Huang, A. M., Jhan, J. H., Wu, W. J., Li, C. C., Lee, H. Y., Yeh, H. C., and Ke, H. L. (2021) High Transaldolase 1 expression predicts poor survival of patients with upper tract urothelial carcinoma. Pathol Int 71, 463-470

     

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