Featured publication2026 · Cancer Genomics & Proteomics
UTUCResearch Laboratory
01 / 05
01 — About us
A focused laboratory
for a complex cancer.
We are a branch of the urothelial cancer research team founded under Professor Wen-Jeng Wu. With focused resources and collaborative effort, we aim to add a meaningful piece to the treatment blueprint for UTUC.
UTUC has an unusually high incidence in Taiwan. Our laboratory studies the distinctive environmental, genetic and molecular factors behind this disease, connecting cell biology, multi-omics and clinical pathology to identify biomarkers and new therapeutic strategies.
Start a collaboration15+prognostic molecules investigated
4integrated research programs
1shared goal: better UTUC care
02 — Research topics
From mechanism
to therapeutic opportunity.
Our work connects tumor-intrinsic signaling with metabolism, stress adaptation, extracellular matrix and immune escape.
Non-coding RNA regulation
Decoding miRNA–mRNA and lncRNA–miRNA networks that govern UTUC progression, including miR-145-5p/ARF6, miR-145-5p/ATIC, miR-375-3p/DERL1 and emerging regulatory axes.
ER homeostasis & proteostasis
Understanding how SSR/TRAP, DERL1/ERAD, PON and stress-adaptive pathways sustain protein handling, survival and treatment resistance in urothelial cancer.
Metabolism & ferroptosis
Investigating ATIC-dependent purine metabolism and STEAP-linked iron metabolism–ferroptosis resistance as actionable vulnerabilities in UTUC.
Tumor microenvironment
Mapping extracellular matrix, immune checkpoint and macrophage signals—including VCAN, B7-H3, CSF-1 and IL-34—that shape invasion and immune escape.
03 — Team members
Clinicians and scientists,
working as one team.
Our multidisciplinary group combines urology, molecular biology, immunology, bioinformatics and translational oncology.
Hung-Lung Ke
柯宏龍
Principal Investigator · Professor & Urologist
Jhen-Hao Jhan
詹鎮豪
Urologist · Clinical Researcher
Hui-Hui Lin
林慧惠
Assistant Professor · Immunology & Oncology
Wei-Chi Hsu
徐偉齊
Postdoctoral Researcher · Molecular Oncology
Chien-Sheng Wang
王建勝
Urologist · Clinical Researcher
Che-Wei Chang
張哲維
Urologist · Bioinformatics
Yi-Ru Wu
吳奕儒
Urology Resident · Clinical Researcher
04 — Research grants
Supported research.
Measurable progress.
Selected projects supported by national and institutional programs.
探討非編碼核糖核酸調控 ADAM 在上泌尿道上皮癌之相關分子機轉及治療潛力（3/3）
Principal investigator建構多體學與人工智慧加值的尿路上皮癌生醫資料庫：從大數據到精準醫學（1/4）
Co-investigator解碼 USP2 的去泛素化作用標的與廣泛性細胞程序式死亡對泌尿上皮癌進程和化療抗藥性的機轉
Co-investigator以次世代定序和基因剔除探討 DERL1 及其下游基因於上泌尿道上皮癌之功能及對順鉑敏感性的分子機轉
Research project完整歷年研究計畫47 projects
Hung-Lung Ke
114 (一般研究計畫) 探討非編碼核糖核酸調控ADAM在上泌尿道上皮癌之相關分子機轉及治療潛力(3/3) (計畫主持人)
114 (延攬博士後研究人才) 探討非編碼核糖核酸調控ADAM在上泌尿道上皮癌之相關分子機轉及治療潛力(3/3) (計畫主持人)
114 (一般策略專案計畫) A-建構多體學與人工智慧加值的尿路上皮癌生醫資料庫：從大數據到精準醫學(1/4) (共同主持人)
114 (一般研究計畫) 剖析PPP2R2B於尿路上皮癌之臨床、生物及及治療意涵(3/3) (共同主持人)
114 (一般研究計畫) 解碼USP2的去泛素化作用標的與廣泛性細胞程序式死亡對泌尿上皮癌的進程和化療抗藥性的機轉 (共同主持人)
113 (一般研究計畫) 探討非編碼核糖核酸調控ADAM在上泌尿道上皮癌之相關分子機轉及治療潛力(2/3) (計畫主持人)
113 (延攬博士後研究人才) 探討非編碼核糖核酸調控ADAM在上泌尿道上皮癌之相關分子機轉及治療潛力(2/3) (計畫主持人)
113 (一般研究計畫) 剖析PPP2R2B於尿路上皮癌之臨床、生物及及治療意涵(2/3) (共同主持人)
113 (新進人員研究計畫) 以次世代定序和基因剔除探討Derlin1及其下游基因於上泌尿道上皮癌之功能及對順鉑敏感性的分子機轉 (共同主持人)
112 (延攬博士後研究人才) 探討非編碼核糖核酸調控ADAM在上泌尿道上皮癌之相關分子機轉及治療潛力(1/3) (計畫主持人)
112 (一般研究計畫) 探討非編碼核糖核酸調控ADAM在上泌尿道上皮癌之相關分子機轉及治療潛力(1/3) (計畫主持人)
112 (新進人員研究計畫) 剖析 Derlin1在上泌尿道上皮癌之分子傳遞訊息及對化療藥物抗藥性的影響 (共同主持人)
112 (一般研究計畫) 剖析PPP2R2B於尿路上皮癌之臨床、生物及及治療意涵(1/3) (共同主持人)
111 (一般研究計畫) 探討腎移植後泌尿上皮癌發生之NTRK3基因變異在泌尿上皮癌細胞的分子傳遞訊息及相關分子抑制劑之評估 (共同主持人)
111 (延攬博士後研究人才) 探討非編碼核糖核酸在上泌尿道上皮癌的侵襲和轉移分子機轉 (計畫主持人)
110 (延攬博士後研究人才) 探討非編碼核糖核酸在上泌尿道上皮癌的侵襲和轉移分子機轉 (計畫主持人)
110 (一般研究計畫) NTRK3基因的變異對腎移植後泌尿上皮癌發生的分子機制及潛在應用 (共同主持人)
109 (一般研究計畫) 剖析CEBPD和MYC基因共同放大於尿路上皮癌之生物意義、醣類代謝及治療潛力 (共同主持人) 3年期計畫
109 (一般研究計畫) 探討非編碼核糖核酸在上泌尿道上皮癌的侵襲和轉移分子機轉 (計畫主持人) 3年期計畫
109 (一般研究計畫) 腎移植病患術後發生泌尿上皮細胞癌之相關分子機轉探討 (共同主持人)
108 (一般研究計畫) 探討DPYSL3基因在泌尿上皮癌過度活化之致腫瘤機轉及治療意涵 (共同主持人)
108 (一般研究計畫) 探討長鏈非編碼核糖核酸和微小核醣核酸在上泌尿道上皮癌的抗藥性機轉 (計畫主持人)
108 (一般研究計畫) CEBPD透過調控微核糖核酸miR-17-92 cluster在上/泌尿上皮癌的進程及抗藥性發展的機轉探討 (共同主持人)
107 (一般研究計畫) 探討微小核糖核酸調控CSF-1和IL-34在上泌尿道上皮癌腫瘤微環境與免疫反應之機轉 (計畫主持人)
107 (一般研究計畫) 研究DHRS2在尿路上皮癌所扮演的角色 (共同主持人)
107 (一般研究計畫) CEBPD與其標的微型核糖核酸在泌尿上皮癌的進程及抗藥性發展的角色及機轉探討 (共同主持人)
106 (一般研究計畫) 研究糖解路徑及其相關microRNA在上泌尿道上皮癌的致癌機轉 (計畫主持人)
106 (一般研究計畫) 研究Metallothionein在尿路上皮癌所扮演的角色 (共同主持人)
103 (一般研究計畫) 微小核醣核酸在上泌尿上皮癌的致癌機轉 (計畫主持人) 3年期計畫
101 (新進人員研究計畫) microRNA 生成相關基因的SNP與上泌尿道上皮癌發生及預後相關性 (計畫主持人)
KMUH109-9R65 (獎勵型計畫) 探討非編碼核糖核酸在上泌尿道上皮癌的侵襲和轉移分子機轉 I
KMUH108-8R52 (獎勵型計畫) 探討長鏈非編碼核糖核酸和微小核糖核酸在上泌尿道上皮癌的抗藥性機轉
KMUH106-6R59 (獎勵型計畫) 研究糖解路徑及其相關 microRNA 尿道上皮癌的致癌機轉
KMUH105-5R70 (獎勵型計畫) 微小核醣核酸在上泌尿道上皮癌的致癌機轉 III
KMUH104-4R43 (獎勵型計畫) 微小核醣核酸在上泌尿道上皮癌的致癌機轉 II
KMUH103‐3T11 (獎勵型計畫) 微小核醣核酸在上泌尿道上皮癌的致癌機轉 I
kmtth-112-R08 (獎勵型計畫) 探討非編碼核糖核酸調控ADAM在上泌尿道上皮癌之相關分子機轉及治療潛力(1/3)
kmtth-111-R005 (獎勵型計畫) 探討非編碼核糖核酸在上泌尿道上皮癌的侵襲和轉移分子機轉 I I I
kmtth-110-R01 (獎勵型計畫) 探討非編碼核糖核酸在上泌尿道上皮癌的侵襲和轉移分子機轉 I I
(2024) CMRPG8P0571
(2023) 研究miR-145-5p/ATIC在上泌尿道上皮癌的角色及對cisplatin影響癌細胞之效果與分子機制探討(2/2)
(2022) 研究miR-145-5p/ATIC在上泌尿道上皮癌的角色及對cisplatin影響癌細胞之效果與分子機制探討(1/2)
Jhen-Hao Jhan
113 (新進人員研究計畫) 以次世代定序和基因剔除探討Derlin1及其下游基因於上泌尿道上皮癌之功能及對順鉑敏感性的分子機轉 (計畫主持人)
112 (新進人員研究計畫) 剖析 Derlin1在上泌尿道上皮癌之分子傳遞訊息及對化療藥物抗藥性的影響 (計畫主持人)
KMUH107-7M28 (指導型計畫) 研究上泌尿上皮癌其 Derlin-1 與 miRNA 的交互作用機制
H-112-08 (獎勵型計畫) 剖析 Derlin1在上泌尿道上皮癌之分子傳遞訊息及對化療藥物抗藥性的影響
Chien-Sheng Wang
KMUH111-1M46 (指導型計畫) 研究微小核醣核酸miR-299-3p在上泌尿道上皮癌調控VEGFA的角色和分子機轉
05 — Selected publications
The complete
publication archive.
原站全部論文條目已整合於此，可依成員、年份或關鍵字搜尋。
View ORCID222 of 222 records
Huang, T. H., Li, W. M., Ke, H. L., Li, C. C., Wu, W. J., Yeh, H. C., Wang, Y. C., and Lee, H. Y. (2025) The factors impacting on Gleason score upgrading in prostate cancer with initial low Gleason scores. J Formos Med Assoc 124, 145-150.
Hung-Lung Ke
Lin, T. C., Chen, G. H., Yeh, C. C., Ke, H. L., Li, W. M., Tsai, Y. C., Wu, S. Y., Huang, C. Y., Chen, C. H., Lin, W. R., Chen, M., Lo, S. H., Pang, S. T., and Lin, P. H. (2024) No difference in oncological outcomes and perioperative complications between patients with ESRD with unilateral and bilateral UTUC receiving radical nephroureterectomy. Sci Rep 14, 17766
Hung-Lung Ke
Lim, L. M., Lee, Y. C., Lin, T. W., Hong, Z. X., Hsu, W. C., Ke, H. L., Hwang, D. Y., Chung, W. Y., Li, W. M., Lin, H. H., Kuo, H. T., and Huang, A. M. (2024) NTRK3 exhibits a pro-oncogenic function in upper tract urothelial carcinomas. Kaohsiung J Med Sci 40, 445-455
Hung-Lung Ke
Tu, K. Y., Li, C. C., Li, W. M., Yeh, H. C., Ke, H. L., Wu, W. J., Chien, T. M., Wen, S. C., Wang, Y. C., and Lee, H. Y. (2024) Lipid Profiles Impact on the Oncologic Outcome of Upper Tract Urothelial Carcinoma. World J Oncol 15, 287-297
Hung-Lung Ke
Liang, P. I., Wei, Y. C., Chen, H. D., Ma, Y. C., Ke, H. L.,Chien, C. C., and Chuang, H. W. (2024) TGFB1I1 promotes cell proliferation and migration in urothelial carcinoma. KaohsiungJ Med Sci 40, 269-279
Hung-Lung Ke
Wang, C.S., Lee, Y.C., Jhan, J.H., Li, W.M., Chang, L.L., Huang, A.M., Lin, H.H., Wu, Y.R., Hsu, W.C.*, and Ke, H.L.*, 2024. MicroRNA-299-3p inhibits cell proliferation, motility, invasion and angiogenesis via VEGFA in upper tract urothelial carcinoma. J Gene Med . 26: e3616.
Hung-Lung Ke
Wang, C.S., Lee, Y.C., Jhan, J.H., Li, W.M., Chang, L.L., Huang, A.M., Lin, H.H., Wu, Y.R., Hsu, W.C.*, Ke, H.L.*, 2024. MicroRNA-299-3p inhibits cell proliferation, motility, invasion and angiogenesis via VEGFA in upper tract urothelial carcinoma. J Gene Med . 26: e3616.
Jhen-Hao Jhan
Li, W.M., Chan, T.C., Wei, Y.C., Li, C.F., Ke, H.L., Wu, W.J., Hsu, C.C., Wang, S.C., Yeh, C.F., 2023. Downregulation of CRTAC1 in Urothelial Carcinoma Promotes Tumor Aggressiveness and Confers Poor Prognosis. Front Biosci (Landmark Ed) 28, 217.
Hung-Lung Ke
Luo, H.L., Lee, Y.C., Chang,Y.L., Hsu, W.C., Wu, Y.T., Jhan, J.H., Lin, H.H., Wu, Y.R., Ke, H.L.*, and Liu, H.Y.*, 2023. MicroRNA-145-5p suppresses cell proliferation, migration, and invasion in upper tract urothelial carcinoma by targeting 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase. J Cell Biochem . 124, 1324-1345.
Hung-Lung Ke
Lee, M.R., Li, W.M., Li, C.C., Chou, Y.H., Wu, W.J., Juan,Y.S., Ke, H.L., Wen, S.C., Lee, H.Y., Chien, T.M., 2023. Cumulative sumanalysis of the learning curve of laparoendoscopic single-site robot-assisted radical prostatectomy. Asian J Surg. 46, 3614-3619.
Hung-Lung Ke
Jhan, J.H., Ke, H.L., Liang, P.I., Hsu, W.C., Lee, Y.C., Lin, H.H., Wu, Y.R., Huang, A.M., Lee, H.Y., Yeh, H.C., Wu, W.J., Li, C.C., Li, W.M., 2023. High MRE11 Expression Level Predicts Poor Survival in Upper Tract Urothelial Carcinomas. Appl Immunohistochem Mol Morphol 31, 94-100.
Hung-Lung Ke
Chen, Y.H., Geng, J.H., Shen, J.T., Lee, Y.C., Jhan, J.H.*, 2023a. Penile squamous cell carcinoma originating from a silicone granuloma. Urol Case Rep 51, 102595.
Jhen-Hao Jhan
Luo, H.L., Lee, Y.C., Chang,Y.L., Hsu, W.C., Wu, Y.T., Jhan, J.H., Lin, H.H., Wu, Y.R., Ke, H.L.*, Liu, H.Y.*, 2023. MicroRNA-145-5p suppresses cell proliferation, migration, and invasion in upper tract urothelial carcinoma by targeting 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase. J Cell Biochem . 124, 1324-1345.
Jhen-Hao Jhan
Chen, Y.H., Lee, J.I., Shen, J.T., Wu, Y.H., Tsao, Y.H., Jhan, J.H., Wang, H.S., Lee, Y.C., Huang, S.P., Chen, S.C., Geng, J.H., 2023. The impact of secondhand smoke on the development of kidney stone disease is not inferior to that of smoking: a longitudinal cohort study. BMC Public Health 23, 1189.
Jhen-Hao Jhan
Tang, T.Y., Lee, J.I., Shen, J.T., Lee, Y.C., Wang, H.S., Tsao, Y.H., Wu, Y.H., Huang, S.P., Chen, S.C., Jhan, J.H., Geng, J.H., 2023. The association between menopause, postmenopausal hormone therapy, and kidney stone disease in Taiwanese women. Ann Epidemiol 78, 13-18.
Jhen-Hao Jhan
Liu, C.C., Huang, S.P., Lee, Y.C., Lee, C.H., Huang, T.Y., Geng, J.H., Chang, C.W., Lin, C.Y., Juan, Y.S., Wu, W.J., Hsieh, T.J., 2023. Metabolic dysfunction-associated fatty liver disease is an early predictor for testosterone deficiency in aging men without metabolic syndrome. Front Endocrinol (Lausanne) 14, 1252774.
Che-Wei Chang
Wu, K.H., Chang, C.H., Wu, H.C., Huang, S.K., Liu, C.L., Yang, C.K., Li, J.R., Tseng, J.S., Lin, W.R., Yu, C.C., Lo, C.W., Huang, C.Y., Chen, C.H., Tsai, C.Y., Cheng, P.Y., Jiang, Y.H., Lee, Y.K., Chen, Y.T., Yeh, T.C., Lin, J.T., Tsai, Y.C., Hsueh, T.Y., Chiang, B.J., Chiang, Y.D., Lin, W.Y., Jou, Y.C., Pang, S.T., Ke, H.L.*, 2022. Oncologic impact of delay between diagnosis and radical nephroureterectomy. Front Oncol 12, 1025668.
Hung-Lung Ke
Lim, L.M., Chung, W.Y., Hwang,D.Y., Yu, C.C., Ke, H.L., Liang, P.I., Lin, T.W., Cheng, S.M., Huang, A.M., Kuo, H.T., 2022. Whole-exome sequencing identified mutational profiles of urothelial carcinoma post kidney transplantation. J Transl Med 20, 324.
Hung-Lung Ke
Yuan, C. H., Hsu, W. C., Huang, A. M., Yuan, B. C., Chen, I. H., Hsu, C. A., Chen, R. F., Chu, Y. M., Lin, H. H., and Ke, H. L*. (2022) MicroRNA-145-5p modulates Kruppel-like factor 5 and inhibits cell proliferation, migration, and invasion in nasopharyngeal carcinoma. BMC Mol Cell Biol 23, 28
Hung-Lung Ke
Yu, C. C., Chen, C. H., Hong, J. H., Ke, H. L., Li, W. M., Chung, S. D., Wu, W. C., Chen, Y. T., Jiang, Y. H., Lin, Y. H., Lin, W. Y., Wu, C. C., and Tsai, Y. C. (2022) Comparison of oncological outcomes for hand-assisted and pure laparoscopic radical nephroureterectomy: results from the Taiwan Upper Tract Urothelial Cancer Collaboration Group. Surg Endosc 36, 4342-4348
Hung-Lung Ke
Lo, C. W., Li, W. M., Ke, H. L., Chang, Y. H., Wu, H. C., Chen, I. A., Lin, J. T., Huang, C. Y., Chen, C. H., Tseng, J. S., Lin, W. R., Jiang, Y. H., Lee, Y. K., Tsai, C. Y., Chung, S. D., Hsueh, T. Y., Chiu, A. W., Jou, Y. C., Cheong, I. S., Chen, Y. T., Chen, J. S., Chiang, B. J., Yu, C. C., Lin, W. Y., Wu, C. C., Chen, C. S., Weng, H. Y., and Tsai, Y. C. (2022) Impact of Adjuvant Chemotherapy on Variant Histology of Upper Tract Urothelial Carcinoma: A Propensity Score-Matched Cohort Analysis. Front Oncol 12, 843715
Hung-Lung Ke
Lin, T. W., Lee, H. Y., Yang, S. F., Li, C. C., Ke, H. L., Li, W. M., Li, C. Y., Tu, H. P., Wu, W. J., and Yeh, H. C. (2022) Perineural Invasion is a Powerful Prognostic Factor for Upper Tract Urothelial Carcinoma Following Radical Nephroureterectomy. Ann Surg Oncol 29, 3306-3317
Hung-Lung Ke
Lim, L. M., Chung, W. Y., Hwang, D. Y., Yu, C. C., Ke, H. L., Liang, P. I., Lin, T. W., Cheng, S. M., Huang, A. M., and Kuo, H. T. (2022) Whole-exome sequencing identified mutational profiles of urothelial carcinoma post kidney transplantation. J Transl Med 20, 324
Hung-Lung Ke
Li, W. M., Ke, H. L., Kuo, Y. H., Lai, H. Y., Chan, T. C., Hsing, C. H., Hsieh, K. L., Li, W. S., Chen, T. J., Wei, Y. C., Wu, W. J., Huang, S. K., and Li, C. F. (2022) High MT2A Expression Predicts Worse Prognosis in Patients with Urothelial Carcinoma. Oncology
Hung-Lung Ke
Lee, M. R., Ke, H. L., Huang, J. C., Huang, S. P., and Geng, J. H. (2022) Obesity-related indices and its association with kidney stone disease: a cross-sectional and longitudinal cohort study. Urolithiasis 50, 55-63
Hung-Lung Ke
Lee, H. Y., Chang, C. H., Huang, C. P., Yu, C. C., Lo, C. W., Chung, S. D., Wu, W. C., Chen, I. A., Lin, J. T., Jiang, Y. H., Lee, Y. K., Hsueh, T. Y., Chiu, A. W., Chen, Y. T., Lin, C. M., Tsai, Y. C., Chen, W. C., Chiang, B. J., Huang, H. C., Chen, C. H., Huang, C. Y., Wu, C. C., Lin, W. Y., Tseng, J. S., Ke, H. L., and Yeh, H. C. (2022) Is Lymph Node Dissection Necessary During Radical Nephroureterectomy for Clinically Node-Negative Upper Tract Urothelial Carcinoma? A Multi-Institutional Study. Front Oncol 12, 791620
Hung-Lung Ke
Ke, H. L., Li, C. C., Lee, H. Y., Tu, H. P., Wei, Y. C., Yeh, H. C., Wu, W. J., and Li, W. M. (2022) Prognostic Value of Comorbidity for Patients with Upper Tract Urothelial Carcinoma after Radical Nephroureterectomy. Cancers (Basel) 14
Hung-Lung Ke
Ke, H. L., Lee, Y. C., Li, W. M., Wang, C. S., Hsu, W. C., Lin, H. H., Lee, Y. A., Jhan, J. H., Li, C. C., Yeh, H. C., Wu, W. J., and Huang, A. M. (2022) High Ubiquitin-Specific Protease 2a Expression Level Predicts Poor Prognosis in Upper Tract Urothelial Carcinoma. Appl Immunohistochem Mol Morphol 30, 304-310
Hung-Lung Ke
Jhan, J. H., Hsu, W. C., Lee, Y. C., Li, W. M., Huang, A. M., Lin, H. H., Wang, C. S., Wu, Y. R., Li, C. C., Wu, W. J., and Ke, H. L*. (2022) MicroRNA-375-3p Suppresses Upper Tract Urothelial Carcinoma Cell Migration and Invasion via Targeting Derlin-1. Cancers (Basel) 14
Hung-Lung Ke
Liu, C. C., Wu, C. F., Lee, Y. C., Huang, T. Y., Huang, S. T., Wang, H. S., Jhan, J. H., Huang, S. P., Li, C. C., Juan, Y. S., Hsieh, T. J., Tsai, Y. C., Chen, C. C., and Wu, M. T. (2022) Genetic Polymorphisms of MnSOD Modify the Impacts of Environmental Melamine on Oxidative Stress and Early Kidney Injury in Calcium Urolithiasis Patients. Antioxidants (Basel) 11
Jhen-Hao Jhan
Li, C. C., Lin, B. S., Wen, S. C., Liang, Y. T., Sung, H. Y., Jhan, J. H., and Lin, B. S. (2022) Smart Blood Vessel Detection System for Laparoscopic Surgery. IEEE J Transl Eng Health Med 10, 2500207
Jhen-Hao Jhan
Jhan, J. H., Hsu, W. C., Lee, Y. C., Li, W. M., Huang, A. M., Lin, H. H., Wang, C. S., Wu, Y. R., Li, C. C., Wu, W. J., and Ke, H. L. (2022) MicroRNA-375-3p Suppresses Upper Tract Urothelial Carcinoma Cell Migration and Invasion via Targeting Derlin-1. Cancers (Basel) 14
Jhen-Hao Jhan
Chang, C. K., Lee, J. I., Chang, C. F., Lee, Y. C., Jhan, J. H., Wang, H. S., Shen, J. T., Tsao, Y. H., Huang, S. P., and Geng, J. H. (2022) Betel Nut Chewing Is Associated with the Risk of Kidney Stone Disease. J Pers Med 12
Jhen-Hao Jhan
Yuan, C. H., Hsu, W. C., Huang, A. M., Yuan, B. C., Chen, I. H., Hsu, C. A., Chen, R. F., Chu, Y. M., Lin, H. H., and Ke, H. L. (2022) MicroRNA-145-5p modulates Kruppel-like factor 5 and inhibits cell proliferation, migration, and invasion in nasopharyngeal carcinoma. BMC Mol Cell Biol 23, 28
Hui-Hui Lin
Lee, H.Y., Wang, C.S., Juan,Y.S., 2022. Detrusor Underactivity in Men with Bladder Outlet Obstruction. Biomedicines 10.
Chien-Sheng Wang
Chang, C.W., Tang, T.Y., Geng, J.H., Jhan, J.H., Wang, H.S., Shen, J.T., Lee, Y.C., 2022. The Safety and Efficacy of Vela Laser En-Bloc Endoscopic Resection versus Conventional Transurethral Resection of Bladder Tumor-A Single Center Experience. J Clin Med 11.
Che-Wei Chang
Yeh, H. C., Li, C. C., Chien, T. M., Li, C. Y., Cheng, Y. C., Woldu, S. L., Robyak, H., Huang, C. N., Ke, H. L., Li, W. M., Lee, H. Y., Yeh, B. W., Yang, S. F., Tu, H. P., Sagalowsky, A. I., Raman, J. D., Singla, N., Margulis, V., Lotan, Y., Hsieh, J. T., and Wu, W. J. (2021) Interethnic differences in the impact of body mass index on upper tract urothelial carcinoma following radical nephroureterectomy. World J Urol 39, 491-500
Hung-Lung Ke
Yeh, C. F., Chan, T. C., Ke, H. L., Chen, T. J., Wu, L. C., Lee, H. Y., Wei, Y. C., Wu, W. J., Li, C. F., and Li, W. M. (2021) Prognostic Significance of ROR2 Expression in Patients with Urothelial Carcinoma. Biomedicines 9
Hung-Lung Ke
Wu, Y. R., Lee, Y. C., Li, W. M., Hsu, W. C., Lin, H. H., Chang, L. L., Huang, A. M., Jhan, J. H., Wu, W. J., Li, C. C., Lee, H. Y., Yeh, H. C., and Ke, H. L*. (2021) High Transaldolase 1 expression predicts poor survival of patients with upper tract urothelial carcinoma. Pathol Int 71, 463-470
Hung-Lung Ke
Wang, C. S., Guu, S. J., Wang, C. J., Yang, S. F., Ke, H. L., Lee, Y. C., and Jhan, J. H. (2021) A rare noncancerous but life-threatening tumor in urinary bladder. Clin Case Rep 9, 1683-1687
Hung-Lung Ke
Su, Y. C., Wen, S. C., Li, C. C., Su, H. C., Ke, H. L., Li, W. M., Lee, H. Y., Li, C. Y., Yang, S. F., Tu, H. P., Wu, W. J., and Yeh, H. C. (2021) Low Hemoglobin-to-Red Cell Distribution Width Ratio Is Associated with Disease Progression and Poor Prognosis in Upper Tract Urothelial Carcinoma. Biomedicines 9
Hung-Lung Ke
Lin, C. H., Wu, W. J., Li, C. C., Ke, H. L., Jhan, J. H., and Wen, S. C. (2021) Comparison of different en bloc holmium laser enucleation of the prostate techniques to reduce the rate of postoperative transient urinary incontinence. J Int Med Res 49, 3000605211037488
Hung-Lung Ke
Li, C. C., Chien, T. M., Lee, M. R., Lee, H. Y., Ke, H. L., Wen, S. C., Chou, Y. H., and Wu, W. J. (2021) Extraperitoneal Robotic Laparo-Endoscopic Single-Site Plus1-Port Radical Prostatectomy Using the da Vinci Single-Site Platform. J Clin Med 10
Hung-Lung Ke
Lee, H. Y., Li, C. C., Li, W. M., Hsu, Y. L., Yeh, H. C., Ke, H. L., Yeh, B. W., Huang, C. N., Li, C. F., Kuo, P. L., and Wu, W. J. (2021) Identification of potential genes in upper tract urothelial carcinoma using next-generation sequencing with bioinformatics and in vitro analyses. PeerJ 9, e11343
Hung-Lung Ke
Lee, H. Y., Chan, E. O., Li, C. C., Leung, D., Li, W. M., Yeh, H. C., Chiu, P. K., Ke, H. L., Yee, C. H., Wong, J. H., Ng, C. F., Teoh, J. Y., and Wu, W. J. (2021) How to manage patients with suspected upper tract urothelial carcinoma in the pandemic of COVID-19? Urol Oncol 39, 733 e711-733 e716
Hung-Lung Ke
Chien, T. M., Lee, H. Y., Singla, N., Margulis, V., Lotan, Y., Woldu, S. L., Huang, C. N., Li, C. C., Ke, H. L., Li, W. M., Li, C. Y., Huang, A. M., Yang, S. F., Tu, H. P., Wu, W. J., and Yeh, H. C. (2021) Prognostic Factors for Contralateral Recurrence of Upper Tract Urothelial Carcinoma after Nephroureterectomy: A Large Multiregional Study. Cancers (Basel) 13
Hung-Lung Ke
Chen, T. J., Chan, T. C., Li, W. S., Li, C. F., Ke, H. L., Wei, Y. C., Wu, W. J., and Li, W. M. (2021) Utility of EFEMP1 in the Prediction of Oncologic Outcomes of Urothelial Carcinoma. Genes (Basel) 12
Hung-Lung Ke
Chang, C. W., Ke, H. L., Lee, J. I., Lee, Y. C., Jhan, J. H., Wang, H. S., Shen, J. T., Tsao, Y. H., Huang, S. P., and Geng, J. H. (2021) Metabolic Syndrome Increases the Risk of Kidney Stone Disease: A Cross-Sectional and Longitudinal Cohort Study. J Pers Med 11
Hung-Lung Ke
Wu, Y. R., Lee, Y. C., Li, W. M., Hsu, W. C., Lin, H. H., Chang, L. L., Huang, A. M., Jhan, J. H., Wu, W. J., Li, C. C., Lee, H. Y., Yeh, H. C., and Ke, H. L. (2021) High Transaldolase 1 expression predicts poor survival of patients with upper tract urothelial carcinoma. Pathol Int 71, 463-470
Jhen-Hao Jhan
Wang, C. S., Guu, S. J., Wang, C. J., Yang, S. F., Ke, H. L., Lee, Y. C., and Jhan, J. H*. (2021) A rare noncancerous but life-threatening tumor in urinary bladder. Clin Case Rep 9, 1683-1687
Jhen-Hao Jhan
Lee, Y. C., Hsieh, T. J., Tang, F. H., Jhan, J. H., Lin, K. L., Juan, Y. S., Wang, H. S., and Long, C. Y. (2021) Therapeutic effect of Low intensity Extracorporeal Shock Wave Therapy (Li-ESWT) on diabetic bladder dysfunction in a rat model. Int J Med Sci 18, 1423-1431
Jhen-Hao Jhan
Chen, C. H., Lee, J. I., Jhan, J. H., Lee, Y. C., Geng, J. H., Chen, S. C., Hung, C. H., and Kuo, C. H. (2021) Secondhand smoke increases the risk of developing kidney stone disease. Sci Rep 11, 17694
Jhen-Hao Jhan
Wang, C. S., Li, C. C., Wu, W. J., Liou, W. C., Lin, Y. E., and Chen, W. C. (2021) Newly designed solid coupling medium for reducing trapped air pockets during extracorporeal shock wave lithotripsy_ a phantom study. BMC Urol 21, 79
Chien-Sheng Wang
Chang, C. W., Yin, H. L., and Li, C. C. (2021) Primary clear cell adenocarcinoma of prostate: A diagnostic challenge. Urol Ann 13, 434-437
Che-Wei Chang
Chang, C. W., Ou, C. H., Yu, C. C., Lo, C. W., Tsai, C. Y., Cheng, P. Y., Chen, Y. T., Huang, H. C., Wu, C. C., Li, C. C., and Lee, H. Y. (2021) Comparative analysis of patients with upper urinary tract urothelial carcinoma in black-foot disease endemic and non-endemic area. BMC Cancer 21, 80
Che-Wei Chang
Chang, C. W., Juan, Y. S., Yang, Y. H., and Lee, H. Y. (2021) The Relationship Between Lower Urinary Tract Symptoms and Severity of Alzheimer's Disease. Am J Alzheimers Dis Other Demen 36, 1533317521992657
Che-Wei Chang
Chang, C. W., Chien, C. C., Juan, Y. S., and Chueh, K. S. (2021) Primary renal angiosarcoma mimicking urothelial carcinoma - A case report and literature reviews. Urol Case Rep 34, 101407
Che-Wei Chang
Yu, L. C., Chang, C. H., Huang, C. P., Huang, C. Y., Hong, J. H., Tai, T. Y., Weng, H. Y., Lo, C. W., Tsai, C. Y., Lee, Y. K., Tsai, Y. C., Hsueh, T. Y., Chen, Y. T., Chen, I. H., Chiang, B. J., Tseng, J. S., Wu, C. C., Lin, W. Y., Chien, T. M., Sheu, Z. L., Li, C. C., Ke, H. L., Li, W. M., Lee, H. Y., Wu, W. J., and Yeh, H. C. (2020) Prognostic Significance of Primary Tumor Location in Upper Tract Urothelial Carcinoma Treated with Nephroureterectomy: A Retrospective, Multi-Center Cohort Study in Taiwan. J Clin Med 9
Hung-Lung Ke
Yeh, H. C., Margulis, V., Singla, N., Hernandez, E., Panwar, V., Woldu, S. L., Karam, J. A., Wood, C. G., Weizer, A. Z., Raman, J. D., Remzi, M., Rioux-Leclercq, N., Haitel, A., Roscigno, M., Bolenz, C., Bensalah, K., Li, C. C., Ke, H. L., Li, W. M., Lee, H. Y., Rapoport, L. M., Lotan, Y., Kapur, P., Shariat, S. F., Hsieh, J. T., and Wu, W. J. (2020) PTRF independently predicts progression and survival in multiracial upper tract urothelial carcinoma following radical nephroureterectomy. Urol Oncol 38, 496-505
Hung-Lung Ke
Yeh, H. C., Li, C. C., Wen, S. C., Singla, N., Woldu, S. L., Robyak, H., Huang, C. N., Ke, H. L., Li, W. M., Lee, H. Y., Li, C. Y., Yeh, B. W., Yang, S. F., Tu, H. P., Shariat, S. F., Sagalowsky, A. I., Raman, J. D., Lotan, Y., Hsieh, J. T., Margulis, V., and Wu, W. J. (2020) Validation of Hyponatremia as a Prognostic Predictor in Multiregional Upper Tract Urothelial Carcinoma. J Clin Med 9
Hung-Lung Ke
Wu, Y. H., Jhan, J. H., Ke, H. L., Tseng, S. I., Chang, Y. H., Yeh, H. C., Li, C. C., and Lee, Y. C. (2020) Risk of developing hypertension after hormone therapy for prostate cancer: a nationwide propensity score-matched longitudinal cohort study. Int J Clin Pharm 42, 1433-1439
Hung-Lung Ke
Li, W. M., Chan, T. C., Huang, S. K., Wu, W. J., Ke, H. L., Liang, P. I., Wei, Y. C., Shiue, Y. L., and Li, C. F. (2020) Prognostic Utility of FBLN2 Expression in Patients With Urothelial Carcinoma. Front Oncol 10, 570340
Hung-Lung Ke
Li, C. C., Chien, T. M., Huang, S. P., Yeh, H. C., Lee, H. Y., Ke, H. L., Wen, S. C., Chang, W. C., Juan, Y. S., Chou, Y. H., and Wu, W. J. (2020) Single-Site Sutureless Partial Nephrectomy for Small Exophytic Renal Tumors. J Clin Med 9
Hung-Lung Ke
Hsu, W. C., Li, W. M., Lee, Y. C., Huang, A. M., Chang, L. L., Lin, H. H., Wu, W. J., Li, C. C., Liang, P. I., and Ke, H. L*. (2020) MicroRNA-145 suppresses cell migration and invasion in upper tract urothelial carcinoma by targeting ARF6. FASEB J 34, 5975-5992
Hung-Lung Ke
Chen, H. W., Tang, J. Y., Chen, Y. C., Wu, W. J., Ke, H. L., and Li, C. C. (2020) Intensity modulation radiation therapy as alternative primary non-surgical treatment of upper tract urothelial carcinoma. Int J Urol 27, 266-268
Hung-Lung Ke
Wu, Y. H., Juan, Y. S., Shen, J. T., Wang, H. S., Jhan, J. H., Lee, Y. C., and Geng, J. H. (2020) Lower urinary tract symptoms-Benign prostatic hyperplasia may increase the risk of subsequent inguinal hernia in a Taiwanese population: A nationwide population-Based cohort study. PLoS One 15, e0234329
Jhen-Hao Jhan
Tsao, Y. H., Hsieh, C. J., Juan, Y. S., Lee, Y. C., Shen, J. T., Wang, H. S., Jhan, J. H., and Geng, J. H. (2020) Herpes zoster and the subsequent risk of prostate cancer in an Asian population: A nationwide population-based cohort study. Medicine (Baltimore) 99, e22441
Jhen-Hao Jhan
Chang, H. H., Jhan, J. H., and Huang, T. Y. (2020) Distal ureteral stone in an ileal conduit: A case treated by antegrade flexible ureteroscopic lithotripsy. Clin Case Rep 8, 2809-2812
Jhen-Hao Jhan
Chang, C. W., Tang, S. H., Su, C. H., Tsai, K. B., Lee, Y. C., and Jhan, J. H*. (2020) IgG4-related disease mimicking renal pelvis tumor with peritoneal carcinomatosis. Clin Case Rep 8, 2040-2045
Jhen-Hao Jhan
Hsu, W. C., Li, W. M., Lee, Y. C., Huang, A. M., Chang, L. L., Lin, H. H., Wu, W. J., Li, C. C., Liang, P. I., and Ke, H. L. (2020) MicroRNA-145 suppresses cell migration and invasion in upper tract urothelial carcinoma by targeting ARF6. FASEB J 34, 5975-5992
Hui-Hui Lin
Wang, C. S., Li, C. C., Juan, Y. S., Wu, W. J., and Lee, H. Y. (2020) 5alpha-reductase inhibitors impact prognosis of urothelial carcinoma. BMC Cancer 20, 872
Chien-Sheng Wang
Chang, C. W., and Huang, C. N. (2020) Pyonephrosis drained by double-J catheter. Clin Case Rep 8, 3586-3587
Che-Wei Chang
Chang, C. W., Tang, S. H., Su, C. H., Tsai, K. B., Lee, Y. C., and Jhan, J. H. (2020) IgG4-related disease mimicking renal pelvis tumor with peritoneal carcinomatosis. Clin Case Rep 8, 2040-2045
Che-Wei Chang
Lee, H. Y., Chen, Y. J., Li, C. C., Li, W. M., Hsu, Y. L., Yeh, H. C., Ke, H. L., Huang, C. N., Li, C. F., Wu, W. J., and Kuo, P. L. (2019) Deduction of Novel Genes Potentially Involved in Upper Tract Urothelial Carcinoma Using Next-Generation Sequencing and Bioinformatics Approaches. Int J Med Sci 16, 93-105
Hung-Lung Ke
Lee, H. Y., Chen, Y. J., Chang, W. A., Li, W. M., Ke, H. L., Wu, W. J., and Kuo, P. L. (2019) Effects of Epigallocatechin Gallate (EGCG) on Urinary Bladder Urothelial Carcinoma-Next-Generation Sequencing and Bioinformatics Approaches. Medicina (Kaunas) 55
Hung-Lung Ke
Jhan, J. H., Lee, Y. C., Li, W. M., Chang, L. L., Hsu, W. C., Lin, H. H., Liang, P. I., Hsu, Y. L., Wu, W. J., Lee, H. Y., Li, C. C., Yeh, H. C., and Ke, H. L*. (2019) The prognostic value of CSN6 expression in upper tract urothelial carcinomas. Kaohsiung J Med Sci 35, 559-565
Hung-Lung Ke
Huang, Y. T., Li, C. C., Chou, Y. H., Ke, H. L., and Chen, C. Y. (2019) Health-related quality of life of exposed versus non-exposed androgen deprivation therapy patients with prostate cancer: a cross-sectional study. Int J Clin Pharm 41, 993-1003
Hung-Lung Ke
Hsu, W. C., Lee, Y. C., Liang, P. I., Chang, L. L., Huang, A. M., Lin, H. H., Wu, W. J., Li, C. C., Li, W. M., Jhan, J. H., and Ke, H. L*. (2019) CSF-1 Overexpression Predicts Poor Prognosis in Upper Tract Urothelial Carcinomas. Dis Markers 2019, 2724948
Hung-Lung Ke
Chen, Y. C., Chen, H. W., Chen, M. T., Huang, C. H., Li, C. C., Juan, Y. S., and Ke, H. L*. (2019) Severe prostate enlargement with severe lower urinary tract symptoms in poorly controlled acromegaly successfully treated with 5alpha-reductase inhibitors: A 15-year longitudinal case report. Low Urin Tract Symptoms 11, O218-O220
Hung-Lung Ke
Chan, T. C., Li, C. F., Ke, H. L., Wei, Y. C., Shiue, Y. L., Li, C. C., Yeh, H. C., Lee, H. Y., Huang, S. K., Wu, W. J., and Li, W. M. (2019) High TNFAIP6 level is associated with poor prognosis of urothelial carcinomas. Urol Oncol 37, 293 e211-293 e224
Hung-Lung Ke
Wang, C. S., Jhan, J. H., and Li, C. C. (2019) Re: Prostate Specific Antigen Density as a Predictor of Clinically Significant Prostate Cancer when the Prostate Specific Antigen is in the Diagnostic Gray Zone: .: A. Aminsharifi, L. Howard, Y. Wu, A. De Hoedt, C. Bailey, S. J. Freedland and T. J. Polascik J Urol 2018; 200: 758-766. J Urol 201, 627-628
Jhen-Hao Jhan
Jhan, J. H., Lee, Y. C., Li, W. M., Chang, L. L., Hsu, W. C., Lin, H. H., Liang, P. I., Hsu, Y. L., Wu, W. J., Lee, H. Y., Li, C. C., Yeh, H. C., and Ke, H. L. (2019) The prognostic value of CSN6 expression in upper tract urothelial carcinomas. Kaohsiung J Med Sci 35, 559-565
Jhen-Hao Jhan
Hsu, W. C., Lee, Y. C., Liang, P. I., Chang, L. L., Huang, A. M., Lin, H. H., Wu, W. J., Li, C. C., Li, W. M., Jhan, J. H., and Ke, H. L. (2019) CSF-1 Overexpression Predicts Poor Prognosis in Upper Tract Urothelial Carcinomas. Dis Markers 2019, 2724948
Jhen-Hao Jhan
Chen, Y. C., Chen, H. W., Juan, Y. S., Lo, I. S., Shih, M. P., Wu, W. J., Jhan, J. H., and Huang, T. Y. (2019) Management of Large Proximal Ureteral Calculi: A Three-year Multicenter Experience of Simultaneous Supine Percutaneous Nephrolithotomy and Retrograde Ureterolithotripsy. Urol J 16, 433-438
Jhen-Hao Jhan
Lu, J. H., Liao, W. T., Lee, C. H., Chang, K. L., Ke, H. L., and Yu, H. S. (2018) DeltaNp63 promotes abnormal epidermal proliferation in arsenical skin cancers. Toxicol In Vitro 53, 57-66
Hung-Lung Ke
Lee, H. Y., Yeh, H. C., Wu, W. J., He, J. S., Huang, C. N., Ke, H. L., Li, W. M., Li, C. F., and Li, C. C. (2018) The diagnostic ureteroscopy before radical nephroureterectomy in upper urinary tract urothelial carcinoma is not associated with higher intravesical recurrence. World J Surg Oncol 16, 135
Hung-Lung Ke
Jhan, J. H., Yeh, H. C., Chang, Y. H., Guu, S. J., Wu, W. J., Chou, Y. H., and Li, C. C. (2018) New-onset diabetes after androgen-deprivation therapy for prostate cancer: A nationwide propensity score-matched four-year longitudinal cohort study. J Diabetes Complications 32, 688-692
Jhen-Hao Jhan
Jhan, J. H., Li, C. C., Wu, W. J., and Lee, H. Y. (2018) Isolated retroperitoneal Castleman's disease: A case report and literature review. Clin Case Rep 6, 1543-1548
Jhen-Hao Jhan
Lin, S. R., Yeh, H. C., Wang, W. J., Ke, H. L., Lin, H. H., Hsu, W. C., Chao, S. Y., Hour, T. C., Wu, W. J., Pu, Y. S., and Huang, A. M. (2017) MiR-193b Mediates CEBPD-Induced Cisplatin Sensitization Through Targeting ETS1 and Cyclin D1 in Human Urothelial Carcinoma Cells. J Cell Biochem 118, 1563-1573
Hung-Lung Ke
Liang, P. I., Yeh, B. W., Li, W. M., Chan, T. C., Chang, I. W., Huang, C. N., Li, C. C., Ke, H. L., Yeh, H. C., Wu, W. J., and Li, C. F. (2017) DPP4/CD26 overexpression in urothelial carcinoma confers an independent prognostic impact and correlates with intrinsic biological aggressiveness. Oncotarget 8, 2995-3008
Hung-Lung Ke
Li, W. M., Huang, C. N., Lee, Y. C., Chen, S. H., Lin, H. H., Wu, W. J., Li, C. C., Yeh, H. C., Chang, L. L., Hsu, W. C., and Ke, H. L*. (2017) Over-expression of Activated Signal Transducer and Activator of Transcription 3 Predicts Poor Prognosis in Upper Tract Urothelial Carcinoma. Int J Med Sci 14, 1360-1367
Hung-Lung Ke
Lee, Y. C., Wu, W. J., Lin, H. H., Li, W. M., Huang, C. N., Hsu, W. C., Chang, L. L., Li, C. C., Yeh, H. C., Li, C. F., and Ke, H. L*. (2017) Prognostic Value of Leptin Receptor Overexpression in Upper Tract Urothelial Carcinomas in Taiwan. Clin Genitourin Cancer 15, e653-e659
Hung-Lung Ke
Lee, H. Y., Yeh, B. W., Chan, T. C., Yang, K. F., Li, W. M., Huang, C. N., Ke, H. L., Li, C. C., Yeh, H. C., Liang, P. I., Shiue, Y. L., Wu, W. J., and Li, C. F. (2017) Sulfatase-1 overexpression indicates poor prognosis in urothelial carcinoma of the urinary bladder and upper tract. Oncotarget 8, 47216-47229
Hung-Lung Ke
Ke, H. L., Li, W. M., Lin, H. H., Hsu, W. C., Hsu, Y. L., Chang, L. L., Huang, C. N., Li, C. C., Chang, H. P., Yeh, H. C., Li, C. F., and Wu, W. J. (2017) Hypoxia-regulated MicroRNA-210 Overexpression is Associated with Tumor Development and Progression in Upper Tract Urothelial Carcinoma. Int J Med Sci 14, 578-584
Hung-Lung Ke
Jhan, J. H., Yang, Y. H., Chang, Y. H., Guu, S. J., and Tsai, C. C. (2017) Hormone therapy for prostate cancer increases the risk of Alzheimer's disease: a nationwide 4-year longitudinal cohort study. Aging Male 20, 33-38
Jhen-Hao Jhan
Li, W. M., Huang, C. N., Lee, Y. C., Chen, S. H., Lin, H. H., Wu, W. J., Li, C. C., Yeh, H. C., Chang, L. L., Hsu, W. C., and Ke, H. L. (2017) Over-expression of Activated Signal Transducer and Activator of Transcription 3 Predicts Poor Prognosis in Upper Tract Urothelial Carcinoma. Int J Med Sci 14, 1360-1367
Hui-Hui Lin
Lee, Y. C., Wu, W. J., Lin, H. H., Li, W. M., Huang, C. N., Hsu, W. C., Chang, L. L., Li, C. C., Yeh, H. C., Li, C. F., and Ke, H. L. (2017) Prognostic Value of Leptin Receptor Overexpression in Upper Tract Urothelial Carcinomas in Taiwan. Clin Genitourin Cancer 15, e653-e659
Hui-Hui Lin
Yeh, H. C., Huang, C. N., Li, C. C., Chang, L. L., Lin, H. H., Ke, H. L., Huang, A. M., Liang, P. I., Li, C. F., and Wu, W. J. (2016) Overexpression of PTP4A3 is associated with metastasis and unfavorable prognosis in bladder cancer. World J Urol 34, 835-846
Hung-Lung Ke
Yeh, H. C., Chien, T. M., Wu, W. J., Li, C. C., Li, W. M., Ke, H. L., Chou, Y. H., Wang, C. J., Huang, S. P., Li, C. F., Liang, P. I., and Huang, C. N. (2016) Is preoperative anemia a risk factor for upper tract urothelial carcinoma following radical nephroureterectomy? Urol Oncol 34, 337 e331-339
Hung-Lung Ke
Tsai, M. C., Li, W. M., Huang, C. N., Ke, H. L., Li, C. C., Yeh, H. C., Chan, T. C., Liang, P. I., Yeh, B. W., Wu, W. J., Lim, S. W., and Li, C. F. (2016) DDR2 overexpression in urothelial carcinoma indicates an unfavorable prognosis: a large cohort study. Oncotarget 7, 78918-78931
Hung-Lung Ke
Li, W. M., Wei, Y. C., Huang, C. N., Ke, H. L., Li, C. C., Yeh, H. C., Chang, L. L., Huang, C. H., Li, C. F., and Wu, W. J. (2016) Matrix metalloproteinase-11 as a marker of metastasis and predictor of poor survival in urothelial carcinomas. J Surg Oncol 113, 700-707
Hung-Lung Ke
Li, W. M., Huang, C. N., Ke, H. L., Li, C. C., Wei, Y. C., Yeh, H. C., Chang, L. L., Huang, C. H., Liang, P. I., Yeh, B. W., Chan, T. C., Li, C. F., and Wu, W. J. (2016) MCM10 overexpression implicates adverse prognosis in urothelial carcinoma. Oncotarget 7, 77777-77792
Hung-Lung Ke
Li, C. C., Yeh, H. C., Lee, H. Y., Li, W. M., Ke, H. L., Hsu, A. H., Lee, M. H., Tsai, C. C., Chueh, K. S., Huang, C. N., Chou, Y. H., Li, C. F., and Wu, W. J. (2016) Laparoscopic partial nephrectomy without intracorporeal suturing. Surg Endosc 30, 1585-1591
Hung-Lung Ke
Chien, T. M., Lu, Y. M., Geng, J. H., Huang, T. Y., Ke, H. L., Huang, C. N., Li, C. C., Chou, Y. H., Wu, W. J., and Huang, S. P. (2016) Predictors of Positive Bone Metastasis in Newly Diagnosed Prostate Cancer Patients. Asian Pac J Cancer Prev 17, 1187-1191
Hung-Lung Ke
Cheng, Y. C., Huang, C. N., Wu, W. J., Li, C. C., Ke, H. L., Li, W. M., Tu, H. P., Li, C. F., Chang, L. L., and Yeh, H. C. (2016) The Prognostic Significance of Inflammation-Associated Blood Cell Markers in Patients with Upper Tract Urothelial Carcinoma. Ann Surg Oncol 23, 343-351
Hung-Lung Ke
Yeh, H. C., Jan, H. C., Wu, W. J., Li, C. C., Li, W. M., Ke, H. L., Huang, S. P., Liu, C. C., Lee, Y. C., Yang, S. F., Liang, P. I., and Huang, C. N. (2015) Concurrent Preoperative Presence of Hydronephrosis and Flank Pain Independently Predicts Worse Outcome of Upper Tract Urothelial Carcinoma. PLoS One 10, e0139624
Hung-Lung Ke
Liang, P. I., Chen, W. T., Li, C. F., Li, C. C., Li, W. M., Huang, C. N., Yeh, H. C., Ke, H. L., Wu, W. J., and Chai, C. Y. (2015) Subcellular localisation of anillin is associated with different survival outcomes in upper urinary tract urothelial carcinoma. J Clin Pathol 68, 1026-1032
Hung-Lung Ke
Lee, H. Y., Li, C. C., Huang, C. N., Li, W. M., Yeh, H. C., Ke, H. L., Yang, K. F., Liang, P. I., Li, C. F., and Wu, W. J. (2015) INHBA overexpression indicates poor prognosis in urothelial carcinoma of urinary bladder and upper tract. J Surg Oncol 111, 414-422
Hung-Lung Ke
Lee, H. Y., Li, C. C., Huang, C. N., Ke, H. L., Li, W. M., Liang, P. I., Yang, S. F., Tu, H. P., Wu, W. J., and Yeh, H. C. (2015) Prognostic significance of lymphovascular invasion in upper urinary tract urothelial carcinoma is influenced by tumor location. Ann Surg Oncol 22, 1392-1400
Hung-Lung Ke
Ke, H. L., Lin, J., Ye, Y., Wu, W. J., Lin, H. H., Wei, H., Huang, M., Chang, D. W., Dinney, C. P., and Wu, X. (2015) Genetic Variations in Glutathione Pathway Genes Predict Cancer Recurrence in Patients Treated with Transurethral Resection and Bacillus Calmette-Guerin Instillation for Non-muscle Invasive Bladder Cancer. Ann Surg Oncol 22, 4104-4110
Hung-Lung Ke
Ke, H. L., Lin, H. H., Li, W. M., Li, C. C., Chang, L. L., Lee, Y. C., Huang, C. N., and Wu, W. J. (2015) High visfatin expression predicts poor prognosis of upper tract urothelial carcinoma patients. Am J Cancer Res 5, 2447-2454
Hung-Lung Ke
Fan, E. W., Li, C. C., Wu, W. J., Huang, C. N., Li, W. M., Ke, H. L., Yeh, H. C., Wu, T. F., Liang, P. I., Ma, L. J., and Li, C. F. (2015) FGF7 Over Expression is an Independent Prognosticator in Patients with Urothelial Carcinoma of the Upper Urinary Tract and Bladder. J Urol 194, 223-229
Hung-Lung Ke
Wei, H., Ke, H. L., Lin, J., Shete, S., Wood, C. G., and Hildebrandt, M. A. (2014) MicroRNA target site polymorphisms in the VHL-HIF1alpha pathway predict renal cell carcinoma risk. Mol Carcinog 53, 1-7
Hung-Lung Ke
Li, W. M., Wu, W. J., Li, C. C., Ke, H. L., Wei, Y. C., Yeh, H. C., Chou, Y. H., Huang, C. H., and Huang, C. N. (2013) The effect of tumor location on prognosis in patients with primary ureteral urothelial carcinoma. Urol Oncol 31, 1670-1675
Hung-Lung Ke
Lee, Y. C., Wu, W. J., Li, W. M., Lin, H. H., Huang, C. N., Chai, C. Y., Chang, L. L., Lin, H. L., and Ke, H. L*. (2013) Prognostic value of p53 protein overexpression in upper tract urothelial carcinomas in Taiwan. Anticancer Res 33, 1091-1098
Hung-Lung Ke
Ke, H. L., Chen, M., Ye, Y., Hildebrandt, M. A., Wu, W. J., Wei, H., Huang, M., Chang, D. W., Dinney, C. P., and Wu, X. (2013) Genetic variations in micro-RNA biogenesis genes and clinical outcomes in non-muscle-invasive bladder cancer. Carcinogenesis 34, 1006-1011
Hung-Lung Ke
Chen, S. H., Wu, W. J., Tu, H. P., Li, W. M., Huang, C. N., Li, C. C., Lin, H. H., and Ke, H. L*. (2013) Glutathione S-transferase expression in upper urinary tract urothelial carcinomas: a Taiwan study. Asian Pac J Cancer Prev 14, 6475-6479
Hung-Lung Ke
Lee, Y. C., Wu, W. J., Li, W. M., Lin, H. H., Huang, C. N., Chai, C. Y., Chang, L. L., Lin, H. L., and Ke, H. L. (2013) Prognostic value of p53 protein overexpression in upper tract urothelial carcinomas in Taiwan. Anticancer Res 33, 1091-1098
Hui-Hui Lin
Chen, S. H., Wu, W. J., Tu, H. P., Li, W. M., Huang, C. N., Li, C. C., Lin, H. H., and Ke, H. L. (2013) Glutathione S-transferase expression in upper urinary tract urothelial carcinomas: a Taiwan study. Asian Pac J Cancer Prev 14, 6475-6479
Hui-Hui Lin
Wei, H., Kamat, A., Chen, M., Ke, H. L., Chang, D. W., Yin, J., Grossman, H. B., Dinney, C. P., and Wu, X. (2012) Association of polymorphisms in oxidative stress genes with clinical outcomes for bladder cancer treated with Bacillus Calmette-Guerin. PLoS One 7, e38533
Hung-Lung Ke
Lin, H. H., Ke, H. L., Wu, W. J., Lee, Y. H., and Chang, L. L. (2012) Hypermethylation of E-cadherin, p16, p14, and RASSF1A genes in pathologically normal urothelium predict bladder recurrence of bladder cancer after transurethral resection. Urol Oncol 30, 177-181
Hung-Lung Ke
Ke, H. L., Tu, H. P., Lin, H. H., Chai, C. Y., Chang, L. L., Li, W. M., Li, C. C., Lee, Y. C., Yeh, H. C., Wu, W. J., and Bau, D. T. (2012) Cyclooxygenase-2 (COX-2) up-regulation is a prognostic marker for poor clinical outcome of upper tract urothelial cancer. Anticancer Res 32, 4111-4116
Hung-Lung Ke
Chang, W. S., Ke, H. L., Tsai, C. W., Lien, C. S., Liao, W. L., Lin, H. H., Lee, M. H., Wu, H. C., Chang, C. H., Chen, C. C., Lee, H. Z., and Bau, D. T. (2012) The role of XRCC6 T-991C functional polymorphism in renal cell carcinoma. Anticancer Res 32, 3855-3860
Hung-Lung Ke
Wu, H. C., Chang, C. H., Ke, H. L., Chang, W. S., Cheng, H. N., Lin, H. H., Wu, C. Y., Tsai, C. W., Tsai, R. Y., Lo, W. C., and Bau, D. T. (2011) Association of cyclooxygenase 2 polymorphic genotypes with prostate cancer in taiwan. Anticancer Res 31, 221-225
Hung-Lung Ke
Lin, H. H., Ke, H. L., Hsiao, K. H., Tsai, C. W., Wu, W. J., Bau, D. T., and Chang, L. L. (2011) CCND1 1722 polymorphism and potential relevance to upper tract urothelial cancer. Anticancer Res 31, 1043-1047
Hung-Lung Ke
Lin, H. H., Ke, H. L., Hsiao, K. H., Tsai, C. W., Wu, W. J., Bau, D. T., and Chang, L. L. (2011) Potential role of CCND1 G870A genotype as a predictor for urothelial carcinoma susceptibility and muscle-invasiveness in Taiwan. Chin J Physiol 54, 196-202
Hung-Lung Ke
Ke, H. L., Chang, L. L., Yang, S. F., Lin, H. H., Li, C. C., Wu, D. C., and Wu, W. J. (2011) Osteopontin overexpression predicts poor prognosis of upper urinary tract urothelial carcinoma. Urol Oncol 29, 703-709
Hung-Lung Ke
Chou, Y. H., Li, C. C., Hsu, H., Chang, W. C., Liu, C. C., Li, W. M., Ke, H. L., Lee, M. H., Liu, M. E., Pan, S. C., and Wang, H. S. (2011) Renal function in patients with urinary stones of varying compositions. Kaohsiung J Med Sci 27, 264-267
Hung-Lung Ke
Yeh, H. C., Huang, C. H., Yang, S. F., Li, C. C., Chang, L. L., Lin, H. H., Ke, H. L., Wei, Y. C., and Wu, W. J. (2010) Nuclear factor-kappaB activation predicts an unfavourable outcome in human upper urinary tract urothelial carcinoma. BJU Int 106, 1223-1229
Hung-Lung Ke
Wu, W. J., Ke, H. L., Yang, Y. H., Li, C. C., Chou, Y. H., and Huang, C. H. (2010) Should patients with primary upper urinary tract cancer receive prophylactic intravesical chemotherapy after nephroureterectomy? J Urol 183, 56-61
Hung-Lung Ke
Liu, C. C., Juan, H. C., Lee, Y. C., Wu, W. J., Wang, C. J., Ke, H. L., Li, W. M., Yeh, H. C., Li, C. C., Chou, Y. H., Huang, C. H., and Huang, S. P. (2010) The impact of physical health and socioeconomic factors on sexual activity in middle-aged and elderly Taiwanese men. Aging Male 13, 148-153
Hung-Lung Ke
Lin, H. H., Ke, H. L., Huang, S. P., Wu, W. J., Chen, Y. K., and Chang, L. L. (2010) Increase sensitivity in detecting superficial, low grade bladder cancer by combination analysis of hypermethylation of E-cadherin, p16, p14, RASSF1A genes in urine. Urol Oncol 28, 597-602
Hung-Lung Ke
Li, W. M., Shen, J. T., Li, C. C., Ke, H. L., Wei, Y. C., Wu, W. J., Chou, Y. H., and Huang, C. H. (2010) Oncologic outcomes following three different approaches to the distal ureter and bladder cuff in nephroureterectomy for primary upper urinary tract urothelial carcinoma. Eur Urol 57, 963-969
Hung-Lung Ke
Liu, C. C., Wu, W. J., Lee, Y. C., Wang, C. J., Ke, H. L., Li, W. M., Hsiao, H. L., Yeh, H. C., Li, C. C., Chou, Y. H., Huang, C. H., and Huang, S. P. (2009) The prevalence of and risk factors for androgen deficiency in aging Taiwanese men. J Sex Med 6, 936-946
Hung-Lung Ke
Li, W. M., Li, C. C., Ke, H. L., Wu, W. J., Huang, C. N., and Huang, C. H. (2009) The prognostic predictors of primary ureteral transitional cell carcinoma after radical nephroureterectomy. J Urol 182, 451-458; discussion 458
Hung-Lung Ke
Lee, Y. C., Wu, W. J., Liu, C. C., Wang, C. J., Li, W. M., Huang, C. H., Yeh, H. C., Ke, H. L., and Huang, S. P. (2009) The associations among eNOS G894T gene polymorphism, erectile dysfunction, and benign prostate hyperplasia-related lower urinary tract symptoms. J Sex Med 6, 3158-3165
Hung-Lung Ke
Shiea, J., Cho, Y. T., Lin, Y. H., Chang, C. W., Lo, L. H., Lee, Y. C., Ke, H. L., Wu, W. J., and Wu, D. C. (2008) Using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry to rapidly screen for albuminuria. Rapid Commun Mass Spectrom 22, 3754-3760
Hung-Lung Ke
Li, C. C., Chang, T. H., Wu, W. J., Ke, H. L., Huang, S. P., Tsai, P. C., Chang, S. J., Shen, J. T., Chou, Y. H., and Huang, C. H. (2008) Significant predictive factors for prognosis of primary upper urinary tract cancer after radical nephroureterectomy in Taiwanese patients. Eur Urol 54, 1127-1134
Hung-Lung Ke
Ke, H. L., Wei, Y. C., Yang, S. F., Li, C. C., Wu, D. C., Huang, C. H., and Wu, W. J. (2008) Overexpression of hypoxia-inducible factor-1alpha predicts an unfavorable outcome in urothelial carcinoma of the upper urinary tract. Int J Urol 15, 200-205
Hung-Lung Ke
Hsiao, H. L., Yeh, H. C., Chang, T. H., Ke, H. L., Lin, H. C., Wu, W. J., Huang, C. H., and Lee, Y. C. (2008) Renal collecting duct carcinoma and concomitant bladder urothelial carcinoma: a case report. Kaohsiung J Med Sci 24, 157-162
Hung-Lung Ke
Lee, Y. C., Lin, H. H., Wang, C. J., Liu, C. C., Wu, W. J., Huang, C. H., and Chang, L. L. (2008) The associations among GNB3 C825T polymorphism, erectile dysfunction, and related risk factors. J Sex Med 5, 2061-2068
Hui-Hui Lin
Yeh, H. C., Yang, S. F., Ke, H. L., Lee, K. S., Huang, C. H., and Wu, W. J. (2007) Renal cell carcinoma presenting with skull metastasis: a case report and literature review. Kaohsiung J Med Sci 23, 475-479
Hung-Lung Ke
Lee, Y. C., Huang, C. H., Wang, C. J., Liu, C. C., Wu, W. J., Chang, L. L., and Lin, H. H*. (2007) The associations among eNOS G894T gene polymorphism, erectile dysfunction and related risk factors. BJU Int 100, 1116-1120
Hui-Hui Lin
Chang, L. L., Lin, H. H., Chang, C. Y., and Lu, P. L. (2007) Increased incidence of class 1 integrons in trimethoprim/sulfamethoxazole-resistant clinical isolates of Stenotrophomonas maltophilia. J Antimicrob Chemother 59, 1038-1039
Hui-Hui Lin
Wu, I. C., Wang, S. W., Yang, Y. C., Yu, F. J., Kuo, C. H., Chuang, C. H., Lee, Y. C., Ke, H. L., Kuo, F. C., Chang, L. L., Wang, W. M., Jan, C. M., and Wu, D. C. (2006) Comparison of a new office-based stool immunoassay and (13)C-UBT in the diagnosis of current Helicobacter pylori infection. J Lab Clin Med 147, 145-149
Hung-Lung Ke
Wu, D. C., Wu, I. C., Wang, S. W., Lu, C. Y., Ke, H. L., Yuan, S. S., Wang, Y. Y., Chang, W. H., Wang, T. E., Bair, M. J., and Kuo, F. C. (2006) Comparison of stool enzyme immunoassay and immunochromatographic method for detecting Helicobacter pylori antigens before and after eradication. Diagn Microbiol Infect Dis 56, 373-378
Hung-Lung Ke
Lin, H. C., Wu, W. J., Ke, H. L., and Huang, C. H. (2006) Bladder leiomyoma presenting as voiding dysfunction: a case report. Kaohsiung J Med Sci 22, 154-157
Hung-Lung Ke
Lin, H. C., Shih, P. M., Chang, T. H., Ke, H. L., Wu, W. J., and Huang, C. H. (2006) Successful thrombolytic therapy for bilateral renal infarction: a case report. Kaohsiung J Med Sci 22, 410-414
Hung-Lung Ke
Lin, H. C., Liu, C. C., Kang, W. Y., Ke, H. L., Li, C. C., Wu, W. J., and Huang, C. H. (2006) Huge aggressive angiomyxoma: a case report and literature review. Kaohsiung J Med Sci 22, 301-304
Hung-Lung Ke
Ke, H. L., Lin, H. Y., Jang, M. Y., and Wu, W. J. (2006) Hair as the nidus for bladder calculi formation complicating suprapubic cystostomy catheterization: a case report. Kaohsiung J Med Sci 22, 243-246
Hung-Lung Ke
Hsiao, H. L., Wu, W. J., Chang, M. Y., Ke, H. L., and Huang, C. H. (2006) Unusual case of multilocular cystic nephroma treated with nephron sparing technique: a case report. Kaohsiung J Med Sci 22, 515-518
Hung-Lung Ke
Li, W. M., Wu, W. J., Ke, H. L., Chai, C. Y., Chou, Y. H., and Huang, C. H. (2005) Fibroepithelial polyps causing ureteropelvic junction obstruction in a child. Kaohsiung J Med Sci 21, 282-285
Hung-Lung Ke
Ke, H. L., Hsiao, H. L., Guh, J. Y., Liu, C. S., Huang, C. H., and Wu, W. J. (2005) Primary intrarenal lipoma: a case report. Kaohsiung J Med Sci 21, 383-386
Hung-Lung Ke
Su, C. M., Wu, W. J., Lee, Y. C., Ke, H. L., Chou, Y. H., and Huang, C. H. (2004) Spontaneous dissecting aneurysm of the renal artery: a case report. Kaohsiung J Med Sci 20, 609-611
Hung-Lung Ke
Su, C. M., Lee, Y. C., Wu, W. J., Ke, H. L., Chou, Y. H., and Huang, C. H. (2004) Acute necrotizing ureteritis with obstructive uropathy following instillation of silver nitrate in chyluria: a case report. Kaohsiung J Med Sci 20, 512-515
Hung-Lung Ke
Wu, I. C., Ke, H. L., Lo, Y. C., Yang, Y. C., Chuang, C. H., Yu, F. J., Lee, Y. C., Jan, C. M., Wang, W. M., and Wu, D. C. (2003) Evaluation of a newly developed office-based stool test for detecting Helicobacter pylori: an extensive pilot study. Hepatogastroenterology 50, 1761-1765
Hung-Lung Ke
Chen, C. K., Li, C. C., Ke, H. L., Chou, Y. H., Huang, C. H., and Shih, M. C. (2003) Double J stent forgotten for 7 years: a case report. Kaohsiung J Med Sci 19, 84-87
Hung-Lung Ke
06 — Research environment
Equipment &
shared resources.
01
Cell culture
細胞培養與例行維護所需設備，結合實驗室自購與微免學科共用儀器。
- Cell culture incubator（微免學科共用儀器）
- Bio-safety Cabinet Class II, Type A2／A2型二級生物安全櫃（微免學科共用儀器）
- Thermo Scientific Heraeus Megafuge 16R Centrifuge（微免學科共用儀器）
- Lafil 200 – BioDolphin 大容量廢液抽取系統，1台（自購）
02
Western blot
涵蓋蛋白電泳、轉漬、電源、顯影與膜片孵育流程。
- Mini-PROTEAN Tetra Vertical Electrophoresis Cell，3台（自購）
- Mini Trans-Blot® Cell，3台（自購）
- PowerPac™ Basic Power Supply，1台（自購）
- PowerPac™ HC High-Current Power Supply，1台（自購）
- ChemiDoc Imaging System（醫學院共用儀器）
- Orbital shaker，2台（自購）
03
DNA, RNA & protein extraction
核酸與蛋白質樣本前處理及高速冷凍離心。
- Fresco™ 21 Microcentrifuge（自購）
04
cDNA synthesis & real-time PCR
支援cDNA reverse transcription、miRNA cDNA synthesis與即時定量PCR。
- Eppendorf ThermoMixer® C（自購）
- VeritiPro™ Thermal Cycler（醫學院共用儀器）
- Bio-Rad T100 Thermal Cycler（醫學院共用儀器）
- QuantStudio™ 3 Real-Time PCR System，96-well，0.2 mL，laptop（醫學院共用儀器）
05
Immunofluorescence
細胞螢光影像與蛋白定位觀察。
- Leica DMi8（醫學院共用儀器）
06
Absorbance, luminescence & fluorescence
吸光、冷光與螢光強度的多模式定量分析。
- Agilent BioTek Synergy H1 Multimode Reader（醫學院共用儀器）
07
Flow cytometry
細胞週期、凋亡與多色螢光分析。
- Attune™ NxT Flow Cytometer（醫學院共用儀器）
Advanced shared instruments
其他高階儀器由高雄醫學大學研究資源整合發展中心提供
View core facilities07 — Gallery
The complete
laboratory gallery.
08 — Blog archive
Laboratory
information archive.
The latest information in the laboratory
Archive status
No published Blog posts were present on the original website.
The original Blog collection contained no published posts when archived on 2026-07-26; its page title and description are preserved.
Collaboration starts with a conversation
Let’s move UTUC
research forward.
hunglungke@gmail.com westlife740205@gmail.com
No. 100, Shihcyuan 1st Rd.
Kaohsiung City, Taiwan
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